Cellular Mechanisms and Therapies of Hematologic Malignancies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 February 2026 | Viewed by 2
Special Issue Editors
Interests: hematopoiesis; acute myeloid leukemia; myelodysplastic syndromes; bone marrow microenvironment; epigenetics and post transcriptional RNA processing; R-loop regulation and genomic instability
Special Issue Information
Dear Colleagues,
Hematological malignancies encompass a diverse array of cancers affecting multiple blood lineages. Essentially, hematological malignancies are highly heterogenous originating in the hematopoietic stem cells in the bone marrow. Over the years, global efforts in sequencing have allowed the identification of a diverse array of mutations affecting multiple cellular pathways in various heme malignancies. This represents a significant clinical challenge and limits therapeutic opportunities. Globally, leukemia remains the most common form of hematological malignancy. In adults, acute myeloid leukemia (AML) is the most frequently diagnosed form of leukemia, followed by chronic lymphocytic leukemia (CLL). In contrast, ALL remains the most common subtype of the disease in children. Despite advances in treatment, certain subtypes—such as high-risk AML and relapsed or refractory ALL—continue to show poor prognosis and low long-term survival rates. This underscores the critical need to identify subtype-specific cellular pathways and molecular drivers of leukemogenesis. A deeper understanding of these mechanisms could enable the development of more effective, targeted therapies and reveal novel biomarkers for early diagnosis and risk stratification.
The purpose of this Special Issue is to highlight recent findings regarding cellular mechanisms across various hematological malignancies with an emphasis on potential clinical translation. Its goal is to provide a collection of articles that would address novel cellular mechanisms in various subtypes of hematological malignancies, particularly AML, CLL, and ALL, and emphasize their potential to inform novel therapeutic strategies and ultimately enhance patient outcomes and quality of life.
Dr. Sayantani Sinha
Dr. Stanley Chun-Wei Lee
Guest Editors
Manuscript Submission Information
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Keywords
- AML, ALL and CLL
- targeted therapy
- combination therapy
- small molecule inhibitors
- immunotherapy
- RNA in hematopoiesis
- overcoming resistance
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