Molecular Mechanisms of Treatment Resistance in Prostate Cancer
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 February 2026 | Viewed by 4
Special Issue Editor
Interests: androgen receptor; prostate cancer; treatment resistance; cell signaling pathways; SEMA3C
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metastatic castration-resistant prostate cancer (mCRPC) remains a difficult clinical challenge, driven by tumor heterogeneity, diverse progression pathways and complex resistance mechanisms. This Special Issue, “Molecular Mechanisms of Treatment Resistance in Prostate Cancer”, seeks original research and comprehensive reviews on the following topics:
- Precision systemic therapies, including approaches against traditionally “undruggable” targets.
- Genetic and epigenetic alterations driving disease progression.
- The role of cellular plasticity and lineage reprogramming.
- Tumor microenvironment signaling and therapeutic modulation.
- Mechanisms of resistance to current androgen‐targeted and cytotoxic treatments.
- Immunotherapeutic strategies and combination therapies.
- Targeted radiotherapy, including radioligand approaches.
- Novel biomarkers for patient stratification and treatment response monitoring.
The aim of this Special Issue is to deepen our understanding of the complex mechanisms driving mCRPC and to showcase innovative therapeutic avenues that can improve patient survival and quality of life.
Dr. Christopher J. Ong
Guest Editor
Manuscript Submission Information
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Keywords
- metastatic castration-resistant prostate cancer (mCRPC)
- molecular mechanisms
- novel treatment strategies
- systemic precision treatments
- epigenetics
- cellular plasticity
- tumor microenvironment signaling
- therapeutic resistance
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