Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies
edited by Xiangguo Shi
submission deadline 20 Dec 2025 | Viewed by 44 | Submission Open
Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution
(This special issue belongs to the Section Cellular Pathology)
Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions
edited by
submission deadline 20 Dec 2025 | Viewed by 30 | Submission Open
Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function
Clockwork Cells: Decoding the Language of Cell Cycle Regulators
edited by , Kyung-sang Lee, and
submission deadline 20 Dec 2025 | Viewed by 24 | Submission Open
Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis
(This special issue belongs to the Section Cell Proliferation and Division)
Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
edited by and Hisao Moriya
submission deadline 24 Dec 2025 | Viewed by 48 | Submission Open
Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 25 Dec 2025 | 1 articles | Viewed by 1611 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 25 Dec 2025 | Viewed by 568 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
(This special issue belongs to the Section Cell Microenvironment)
Advances in Molecular Genomics and Pathology of Cancers
edited by
submission deadline 25 Dec 2025 | Viewed by 135 | Submission Open
Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Dec 2025 | Viewed by 68 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
Role of T Cells in Immune Disease Treatment
edited by
submission deadline 25 Dec 2025 | Viewed by 41 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells
(This special issue belongs to the Section Cellular Immunology)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 26 Dec 2025 | Viewed by 276 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 28 Dec 2025 | Viewed by 45 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cells of the Nervous System)
Regulation of Ca2+ Signals in Human Disease
edited by Yandong Zhou
submission deadline 28 Dec 2025 | Viewed by 13 | Submission Open
Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets
(This special issue belongs to the Section Cell Signaling)
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 30 Dec 2025 | Viewed by 491 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Fertility Disorders in Testes and Ovaries
edited by Paweł Kordowitzki and Joanna Kochan
submission deadline 30 Dec 2025 | Viewed by 89 | Submission Open
Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF
(This special issue belongs to the Section Tissues and Organs)
Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights
edited by and
submission deadline 30 Dec 2025 | Viewed by 52 | Submission Open
Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy
(This special issue belongs to the Section Tissues and Organs)
Emerging Roles of Glial Cells in Human Health and Disease submission deadline 31 Dec 2025 | 9 articles | Viewed by 26646 | Submission Open
Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia
(This special issue belongs to the Section Cells of the Nervous System)
Gene Therapy for Rare Diseases
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 21495 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction
edited by Zhengui Zheng, and Liang Ma
submission deadline 31 Dec 2025 | 7 articles | Viewed by 10575 | Submission Open
Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6444 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6417 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise submission deadline 31 Dec 2025 | 2 articles | Viewed by 6163 | Submission Open
Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia
(This special issue belongs to the Section Tissues and Organs)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 2 articles | Viewed by 4866 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3992 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3783 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3561 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3435 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2925 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2335 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 2299 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1921 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1443 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1411 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1291 | Submission Open
Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity
(This special issue belongs to the Section Cellular Immunology)
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 927 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 898 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 828 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | Viewed by 739 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 710 | Submission Open
Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites
(This special issue belongs to the Section Cells of the Nervous System)
Epigenetic Mechanisms and Aging
edited by
submission deadline 31 Dec 2025 | Viewed by 380 | Submission Open
Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 240 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Dec 2025 | Viewed by 218 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Dec 2025 | Viewed by 208 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 178 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
How Does Gene Regulation Affect Cancer Development? submission deadline 31 Dec 2025 | Viewed by 164 | Submission Open
Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs
(This special issue belongs to the Section Cell Microenvironment)
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Dec 2025 | Viewed by 149 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Dec 2025 | Viewed by 128 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Immunology and Immune Therapies for Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology
(This special issue belongs to the Section Cell Microenvironment)
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