Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomolecular Condensates in Oncology and Immunology submission deadline 25 Nov 2025 | Viewed by 410 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
CAR T Cells in Human Cancers submission deadline 25 Nov 2025 | Viewed by 57 | Submission Open
Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering
Cell Signaling in Neurodegeneration Disease
edited by , Yasuhiro Funahashi, , and Md-nadim Hossain
submission deadline 25 Nov 2025 | Viewed by 54 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cells of the Nervous System)
Cellular Senescence and Senotherapies in the Aging Retina
edited by
submission deadline 28 Nov 2025 | Viewed by 259 | Submission Open
Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy
(This special issue belongs to the Section Cellular Aging)
Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)
edited by Laxman Gangwani
submission deadline 28 Nov 2025 | Viewed by 103 | Submission Open
Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments
(This special issue belongs to the Section Cellular Pathology)
Cell-to-Cell Crosstalk as a Target of Therapies submission deadline 30 Nov 2025 | 2 articles | Viewed by 5199 | Submission Open
Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis
(This special issue belongs to the Section Cell Microenvironment)
Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy
edited by Behzad M. Toosi and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3716 | Submission Open
Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology
(This special issue belongs to the Section Cell Microenvironment)
Recent Advances in Metabolism and Oxidative Stress in Human Diseases 2.0
edited by and Vanessa Cossu
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3380 | Submission Open
Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism
(This special issue belongs to the Section Cellular Metabolism)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2812 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 2283 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Research on Spinal Cord Injury
edited by and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1743 | Submission Open
Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms in Mitochondrial Function and Calcium Signaling
edited by Sergio De la Fuente and Jaime Santo-Domingo
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1742 | Submission Open
Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling
(This special issue belongs to the Section Cellular Metabolism)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer
edited by Sumit Sen Santara, , Weshely Kujur and Sachin Mulik
submission deadline 30 Nov 2025 | 3 articles | Viewed by 1482 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions
edited by and Susanta Pahari
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1099 | Submission Open
Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use
(This special issue belongs to the Section Cellular Immunology)
Genetic and Cellular Basis of Autoimmune Diseases
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 806 | Submission Open
Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes
(This special issue belongs to the Section Cellular Immunology)
Updates of Stem Cell Applications in Bone Tissue Engineering
edited by Fahad Karim Kidwai
submission deadline 30 Nov 2025 | 1 articles | Viewed by 738 | Submission Open
Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells
(This special issue belongs to the Section Stem Cells)
Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression
edited by and Sudheer Kumar Gara
submission deadline 30 Nov 2025 | Viewed by 552 | Submission Open
Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling
(This special issue belongs to the Section Cellular Pathology)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Nov 2025 | 1 articles | Viewed by 537 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 492 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 419 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 30 Nov 2025 | Viewed by 347 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics
edited by Ben Wielockx
submission deadline 30 Nov 2025 | Viewed by 303 | Submission Open
Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology
(This special issue belongs to the Section Cellular Immunology)
Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 278 | Submission Open
Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain
(This special issue belongs to the Section Cellular Pathology)
CRISPR-Based Genome Editing Approaches in Cancer Therapy
edited by Martin Pal
submission deadline 30 Nov 2025 | Viewed by 213 | Submission Open
Keywords: CRISPR; genome editing; cancer therapy; precision medicine
(This special issue belongs to the Section Cell and Gene Therapy)
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Nov 2025 | Viewed by 103 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
edited by Sauri Hernandez-Resendiz
submission deadline 30 Nov 2025 | Viewed by 81 | Submission Open
Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection
(This special issue belongs to the Section Tissues and Organs)
ROS in Atherosclerosis and Cardiometabolic Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open
Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia
(This special issue belongs to the Section Tissues and Organs)
Molecular Research in Osteoporosis submission deadline 30 Nov 2025 | Viewed by 60 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 30 Nov 2025 | Viewed by 58 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
Microautophagy: The Least Known of the Autophagy Strategies
edited by
submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open
Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs
(This special issue belongs to the Section Autophagy)
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Exclusive Review Issue: Cellular and Nuclear Biomechanics in Cytoskeleton-Driven Migration and Invasion submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open
Keywords: cytoskeletal dynamics; nuclear mechanics; cell migration and invasion; cell division; cell motility and adhesion; mechanotransduction
(This special issue belongs to the Section Cell Motility and Adhesion)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 30 Nov 2025 | Viewed by 23 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Aging)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Nov 2025 | Viewed by 20 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Wound Repair
edited by
submission deadline 30 Nov 2025 | Viewed by 19 | Submission Open
Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 30 Nov 2025 | Viewed by 16 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 30 Nov 2025 | Viewed by 12 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 1 Dec 2025 | Viewed by 132 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 1 Dec 2025 | Viewed by 11 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 5 Dec 2025 | 5 articles | Viewed by 11502 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 10 Dec 2025 | 2 articles | Viewed by 3086 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
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