Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise

Dear Colleagues,

Regular physical exercise improves quality of life, reduces fatigue, positively influences the functional state of body tissues, improves mood, and has a beneficial effect on emotions. It is widely recommended as a basic strategy for the treatment and prevention of many diseases consequent from a bad lifestyle. Exercise exerts a protective and regulatory effect on various metabolic processes, activating adaptive mechanisms based on the regulation of tissue plasticity processes, including the regulation of intracellular pathways. However, it should be applied judiciously and systematically, as inappropriate loads of exercise can cause adverse consequences, including muscle damage, as well as transient damage to other tissues. If the body’s capability of regeneration is exceeded as a result of exercising heavily and frequently without sufficient rest breaks, an overload in the adaptative mechanisms can occur, which can result in the depletion of energy resources, slowing of regeneration, immune dysfunction, frequent infections, chronic fatigue, appetite disorders, sleep disorders, personality changes, etc. The molecular mechanisms involved in these disorders vary depending on the type of tissue/body, and the intensity, duration and type of exercise, as well as individual predisposition.

The benefits of engaging in exercise, however, cannot be underestimated. Its health potential is recognized and exploited in the prevention and treatment of many chronic diseases, as the cross-talk between muscles and other tissues promotes the stimulation of the secretion of substances with regulatory, regenerative, or anti-inflammatory potential.

We will accept manuscripts from different research areas connected with the benefits, pros, and cons of exercise in athletes and in chronic disease, with special emphasis on the biological mechanisms of the changes observed.

Dr. Eugenia Murawska-Ciałowicz
Dr. Ana Filipa Silva
Dr. Gilmara Gomes De Assis
Guest Editors

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