Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1062
Special Issue Editors
Interests: Sjogren's disease; inflammatory myopathies; autoantibodies; type I IFN; systemic autoimmune disorders
Special Issues, Collections and Topics in MDPI journals
Interests: Sjogren's disease; inflammatory myopathies; autoantibodies; type I IFN; systemic autoimmune disorders
Immunogenetics Laboratory, 1st Department of Neurology, Medical School of National and Kapodistrian University of Athens, Aeginition Hospital, Athens, Greece
Interests: systemic autoimmune diseases; autoimmune diseases of CNS; type I interferons and immunopharmacology
Special Issue Information
Dear Colleagues,
Autoantibodies play a crucial role in the pathogenesis and classification of autoimmune diseases, yet new autoantibody profiles have introduced complexities in diagnosis and management. Clinicians encounter difficulties differentiating between overlapping syndromes and recognizing the diagnostic significance of lower titer autoantibodies when forming a conclusive diagnosis.
Substantial evidence so far suggests that both innate and adaptive immunity play significant roles in the pathogenesis of systemic autoimmune diseases like systemic lupus erythematosus, Sjögren’s disease, systemic sclerosis, and inflammatory myopathies with activation of type I interferon and B cell pathways being key pathogenetic determinants. Novel autoantibodies targeting nuclear, nucleolar, and cytoplasmic components are continually being identified. Although ongoing research is focused on understanding how these autoantibodies contribute to clinical presentation and prognosis, their influence on other facets of autoimmune disease pathogenesis—such as early diagnosis and treatment strategies—remains largely unclear.
This issue compiles a series of original research articles, reviews, and case studies that delve into the implications of novel autoantibodies in systemic autoimmunity and, more specifically, the diagnostic utility of these autoantibodies, their association with novel disease phenotypes and their potential as biomarkers for disease progression and treatment response. As autoimmunity continues to evolve, understanding the role of novel autoantibodies will be vital in refining diagnostic criteria and improving patient management.
This Special Issue aims to foster dialogue and collaboration among researchers and clinicians, ultimately enhancing our understanding of systemic autoimmune disorders in the context of novel autoantibody research. We hope it is a valuable resource for advancing the field and improving patient outcomes.
Dr. Clio Mavragani
Dr. Nikolaos Marketos
Dr. Charalampos Skarlis
Guest Editors
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Keywords
- autoantibodies
- autoimmune diseases
- innate and adaptive immunity
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