Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 714
Special Issue Editor
Special Issue Information
Dear Colleagues,
Environmental exposures such as microbes, diet, and pharmaceuticals play a key role in the development and progression of various diseases, particularly metabolic and neuropsychiatric disorders. The complexity of these conditions stems from the interplay between the gut microbiota, their metabolites, host genetics, epigenetics, and the immune system. Recent studies highlight that microbiota-derived metabolites, such as short-chain fatty acids, can modulate epigenetic mechanisms by inhibiting histone deacetylases (HDACs) and altering DNA methylation. These metabolites influence gene expression and impact diverse physiological processes, including immune maturation, immune homeostasis, mucosal barrier integrity, host energy metabolism, and the function of body organs like the brain. This Cells Special Issue will focus on the latest advances in research into the interplay between intestinal bacteria and epigenetic markers in disease pathogenesis. Research papers and reviews examining how diet, bioactive compounds, environmental factors, or how microbiome-based therapies influence health outcomes via epigenetic modulation are welcome. Studies exploring mechanistic links between microbial communities and host gene regulation are also encouraged. By assembling interdisciplinary contributions, this issue aims to advance our understanding of microbiome–epigenome interactions and highlight novel therapeutic opportunities in precision medicine.
Dr. Shabnam Nohesara
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gut microbiome
- epigenetic marks
- metabolic diseases
- neuropsychiatric disorders
- probiotics
- prebiotics
- postbiotics
- indole derivatives
- epigeneic metabolites
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
