Special Issue "Redox and Metabolic Profile of Cancer"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 515

Special Issue Editor

1. Institute for Biological Research "Sinisa Stankovic"—National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
2. Faculty of Biology, University of Belgrade, Belgrade, Serbia
Interests: redox biology; metabolism; redox-metabolic (dys)functions in physiological and pathological conditions; cancer; hibernation; diabetes; aging; mitochondria
* Principal Scientist, Associate Professor

Special Issue Information

Dear Colleagues,

Life is a unity of opposites, and so is the case with aerobic organisms and their evolutionary expansion. With the presence of oxygen, organisms could maximally produce energy in metabolic processes, but reactive species (oxygen, nitrogen, sulfur, etc.) - which are formed as a metabolic ”by”-product, can be lethal - not only damaging major macromolecules but also potentially killing the cell. On the other hand, reactive species play a plethora of regulatory roles within cells and tissues. The evolutionarily conserved interplay between redox and cellular metabolism is strongly manifested in cancer growth.

Metabolic reprogramming of the tumor, discovered by Warburg about 100 years ago, is more relevant today than ever before. Nowadays, cancer is considered a metabolic disease, tightly coupled with redox homeostasis and characterized by an extraordinary capacity for redox-metabolic reprogramming. Metabolic reprogramming, either as a cause or a consequence of the tumorigenesis, is a hallmark characteristic of cancer from tumor initiation and progression to metastasis. Intriguingly, this metabolic switch is a feature not only of cancer cells but also of the surrounding cells in its microenvironment, which they shape together as they re-establish a new tissue homeostasis. To allow cancer growth, cancer cells have an increased need not only for energy but also for the biosynthesis of building blocks, and they generate a unique redox environment not simply to control oxidative stress but also to control the resources necessary for cancer survival.

This Special Issue, entitled “Redox and Metabolic Profile of Cancer”, invites original research and review articles to contribute to the elucidation of the molecular mechanisms of redox-metabolic reprogramming in cancer and the discovery of new therapeutic and research avenues.

Dr. Bato Korac
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • metabolism
  • redox biology
  • redox-metabolic reprogramming
  • reactive species: oxygen, nitrogen, sulfur, etc
  • cancer microenvironment
  • cancer-tissue cooperation
  • mitochondria

Published Papers

This special issue is now open for submission.
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