The Role of T Cells and Cellular Signalling in Immune Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 48
Special Issue Editor
Special Issue Information
Dear Colleagues,
We invite the submission of original research and review papers exploring the critical role of T cells and cellular signalling pathways in immune diseases. Based on their polarisation and cytokine secretion, T cells can be categorised into distinct immune response patterns, including Th1, Th2, Th17, Th22, and Treg cells. T cells are pivotal players in the immune system, recognising pathogens, tumours, and other harmful entities. However, when dysregulated, these cells can contribute to the onset and progression of various autoimmune diseases, chronic inflammation, and immunodeficiencies. These occur in genetically susceptible subjects when they are exposed to endogenous and exogenous triggers. Both susceptibility genes and facilitating conditions have been the focus of intensive research.
Understanding the intricate signalling mechanisms that govern T cell activation, differentiation, expansion, and function is crucial in advancing therapeutic strategies for immune-related diseases. Research in this area can provide promising opportunities to develop targeted treatments to restore immune balance and mitigate the causal pathways of autoimmune diseases.
We encourage the submission of papers that delve into the molecular and cellular processes underlying T cell responses. Furthermore, clinical studies investigating novel biomarkers and therapies targeting T cell signalling pathways are highly encouraged. A special focus will be placed on autoimmune disorders affecting endocrine organs such as the thyroid, adrenal glands, pituitary gland, and pancreas, although papers on other inflammatory conditions are also welcome.
This Special Issue will bring together cutting-edge insights that will contribute to our understanding of immune diseases and promote the development of more effective precision-based treatments.
Dr. Daniela Gallo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- T cells
- autoimmune disorders
- autoimmune endocrine disorders
- targeted therapies
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