Epigenetic Mechanisms and Aging

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 720

Special Issue Editor


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Guest Editor
1. Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore
2. Division of Science, Yale-NUS College, Singapore 138527, Singapore
Interests: WNT; Drosophila; embryology; development; aging; metabolism; stem cells
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Special Issue Information

Dear Colleagues,

Cells have many pathways during the life of an organism: proliferate or die, differentiate or divide, etc. Cells also age and lose the ability to function. The fundamental question as to why this happens is complex, but it is clear that this process can be reversed in some instances. Drosophila melanogaster, or fruit fly, is a model organism with a long history of great contributions to science. As technology has progressed, the great genetic techniques have expanded to incorporating genome editing and many other advances. The short life cycle and conserved cellular processes make Drosophila an ideal model to investigate cellular behavior, especially for cellular pathways in vivo.

We hope that this Special Issue will bring together science utilizing the latest advancements and breakthroughs in cellular aging and behavior. We are looking for investigations and reviews on a wide-ranging list of topics, including signal transduction, cell migration, morphogenesis, homeostasis, polarity and adhesion, especially as these relate to adult tissues.

Dr. Nicholas Tolwinski
Guest Editor

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Keywords

  • drosophila melanogaster
  • model organism
  • cell biology
  • developmental biology
  • genetics
  • molecular biology
  • cell signaling
  • cellular differentiation
  • cell proliferation
  • cell cycle
  • cellular morphogenesis
  • cell-cell communication
  • stem cells
  • cell migration
  • apoptosis
  • cytoskeleton
  • cell adhesion
  • cellular metabolism
  • functional genomics
  • CRISPR/Cas9 in drosophila
  • omics technologies
  • disease models
  • drug discovery
  • regeneration
  • genetic screens
  • cellular stress responses

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Published Papers (1 paper)

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Review

15 pages, 715 KB  
Review
Partial Reprogramming Is Conserved from Insect to Mammal
by Nicholas S. Tolwinski, Sheng Fong, Sujithra Shankar and Jan Gruber
Cells 2026, 15(2), 168; https://doi.org/10.3390/cells15020168 - 16 Jan 2026
Viewed by 115
Abstract
As we become older, systems throughout the body gradually decline in function. Contributing factors include the accumulation of senescent cells and the dysfunction and exhaustion of stem and progenitor cells. A promising approach to mitigate these changes and enhance cellular function in aged [...] Read more.
As we become older, systems throughout the body gradually decline in function. Contributing factors include the accumulation of senescent cells and the dysfunction and exhaustion of stem and progenitor cells. A promising approach to mitigate these changes and enhance cellular function in aged animals is the discovery that differentiated cells retain plasticity, enabling them to revert to pluripotent states when exposed to Yamanaka factors. This method has shown promise in models of rapid aging, and recent studies have demonstrated notable life extension in both flies and mice. These findings, along with the development of senolytics and aging clocks, could revolutionize aging research and interventions. Here, we review recent discoveries in the field and propose new directions for intervention discovery. Full article
(This article belongs to the Special Issue Epigenetic Mechanisms and Aging)
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