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10.5
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Cells
Special Issues
Fertility Disorders in Testes and Ovaries
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Fertility Disorders in Testes and Ovaries

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 856

Special Issue Editors

Prof. Dr. Paweł Kordowitzki

E-Mail Website
Guest Editor
1. Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, Torun, Poland
2. Department of Gynecology, European Competence Center for Ovarian Cancer, Charité, Berlin, Germany
Interests: reproductive aging; epigenetic clocks; telomeres; mitochondria; ovarian cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Joanna Kochan

E-Mail Website
Guest Editor
1. Department of Animal Reproduction, Anathomy and Genomics, University of Agriculture in Krakow, Krakow, Poland
2. Malopolski Institute of Fertility Diagnostics and Treatment-Krakow, Krakow, Poland
Interests: clinical and experimental embryology; IVF; poor ovarian responders; preimplantation genetic testing of embryos

Special Issue Information

Dear Colleagues,

Fertility disorders can arise from various factors affecting the testis and ovary. Genetic abnormalities, hormonal imbalances, and environmental influences are significant contributors. Comprehensive diagnoses involve clinical assessments, laboratory tests, and imaging studies. Treatment options may include hormonal therapies, surgical interventions, or assisted reproductive technologies. Additionally, lifestyle changes, such as diet and stress management, can play a crucial role in improving fertility. Research continues to explore new therapeutic approaches and potential biomarkers for the early detection of reproductive ageing and reproductive pathologies. Epigenetics and genetic counselling may offer insights for affected individuals. Understanding the underlying causes of fertility disorders in the testis and ovary is essential for effective management. Multidisciplinary approaches enhance therapeutic strategies and assisted reproductive technology outcomes, such as in vitro fertilization rates. Therefore, we kindly invite you to contribute to our interesting Special Issue with original articles and reviews from the research fields of medicine, veterinary medicine, basic science, and biology.

Prof. Dr. Paweł Kordowitzki
Prof. Dr. Joanna Kochan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fertility
  • ovary
  • testis
  • aging
  • epigenetics
  • in vitro fertilization
  • IVF

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Published Papers (1 paper)

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Research

12 pages, 2223 KB  
Article
Success Rates of Assisted Reproduction in Couples with Poor Ovarian Response and Oligospermia
by Jakub Wyroba, Joanna Kochan, Maciej Brązert and Paweł Kordowitzki
Cells 2025, 14(19), 1492; https://doi.org/10.3390/cells14191492 - 24 Sep 2025
Viewed by 662
Abstract
Recent progress in assisted reproductive medicine has introduced novel therapeutic possibilities for couples experiencing various reproductive challenges or subfertility. A critical concern in this field is the diminished ovarian response to hormonal treatments preceding ovum pickup, necessitating personalised and optimised protocols to enhance [...] Read more.
Recent progress in assisted reproductive medicine has introduced novel therapeutic possibilities for couples experiencing various reproductive challenges or subfertility. A critical concern in this field is the diminished ovarian response to hormonal treatments preceding ovum pickup, necessitating personalised and optimised protocols to enhance ovarian response across different age groups. Furthermore, a common male factor in IVF couples, oligozoospermia, characterised by a low sperm count, significantly impacts the success rates of assisted reproductive technologies, posing an increasing challenge for in vitro fertilisation clinics. Lifestyle choices, dietary habits, and overall health behaviours have also demonstrably affected fertility outcomes in the 21st century. This original article aims to highlight the synergistic importance of both partners’ health, specifically addressing poor ovarian response and oligozoospermia, in achieving successful conception. Our study analysed intracytoplasmic sperm injection outcomes in couples affected by both aforementioned conditions and proposed an optimal management strategy. This study shows that oligozoospermia significantly reduced ICSI fertilisation and cleavage rates. Poor ovarian responders experienced more cancelled cycles due to fewer embryos. While blastocyst rates relative to zygotes were comparable, overall success was lower in groups with male factor infertility and poor ovarian response, necessitating personalised treatment approaches. Full article
(This article belongs to the Special Issue Fertility Disorders in Testes and Ovaries)
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