Organelle Contact and Its Physiological Implications

Dear Colleagues,

Inter-organelle communication is an emerging and challenging field of study. Dynamic physical and functional associations between different cellular organelles occur at specialized membrane microdomains, known as membrane contact sites (MCSs). These associations regulate crucial physiological processes in eukaryotic cells. Indeed, increasing evidence demonstrates that MSCs represent hotspot signaling domains acting at multiple cellular pathways such as energy and lipid metabolism, ion signaling or proteostasis. Accordingly, impairments in this cross-organelle communication have been associated with multiple pathological conditions, including neurodegeneration, cancer or diabetes.

Contacts between the endoplasmic reticulum and mitochondria are the best-characterized MSCs. Lately, interest has arisen on mapping communication between these and other organelles, such as lysosomes, lysosome-related organelles, peroxisomes, the nucleus or lipid doplets.

This Special Issue will highlight current advances on organelle contacts as key metabolic hubs, focusing on the following fields of study:

1. Regulation and physiological implications of inter-organelle communication.
2. Links between alterations of organelle contacts and disease.
3. Development of methods for visualization and manipulation of inter-organelle communication.
4. Description of new molecular players involved in mediating these junctions.

Dr. Patricia Gómez-Suaga
Dr. Estela Area Gomez
Guest Editors

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