Organelle Contact and Its Physiological Implications

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1781

Special Issue Editors


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Guest Editor
1. Department Biochemistry, Molecular Biology and Genetics, Faculty of Nursing and Occupational Therapy, University of Extremadura, Avda de la Universidad s/n, 10003 Caceres, Spain
2.The Network Center for Biomedical Research in Neurodegenerative Diseases, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), Madrid, Spain
3. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience Maurice Wohl Clinical Neuroscience, Institute King's College London, 5 Cutcombe Road, London SE5 9RX, UK
Interests: mechanisms of neurodegeneration; mitochondria-associated membranes; autophagy; motor neurone disease

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Guest Editor
Centro de Investigaciones Biológicas Margarita Salas-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
Interests: mitochondria-associated membranes; lipid homeostasis; Alzheimer’s disease; neurodegeneration

Special Issue Information

Dear Colleagues,

Inter-organelle communication is an emerging and challenging field of study. Dynamic physical and functional associations between different cellular organelles occur at specialized membrane microdomains, known as membrane contact sites (MCSs). These associations regulate crucial physiological processes in eukaryotic cells. Indeed, increasing evidence demonstrates that MSCs represent hotspot signaling domains acting at multiple cellular pathways such as energy and lipid metabolism, ion signaling or proteostasis. Accordingly, impairments in this cross-organelle communication have been associated with multiple pathological conditions, including neurodegeneration, cancer or diabetes.

Contacts between the endoplasmic reticulum and mitochondria are the best-characterized MSCs. Lately, interest has arisen on mapping communication between these and other organelles, such as lysosomes, lysosome-related organelles, peroxisomes, the nucleus or lipid doplets.

This Special Issue will highlight current advances on organelle contacts as key metabolic hubs, focusing on the following fields of study:

  1. Regulation and physiological implications of inter-organelle communication.
  2. Links between alterations of organelle contacts and disease.
  3. Development of methods for visualization and manipulation of inter-organelle communication.
  4. Description of new molecular players involved in mediating these junctions.

Dr. Patricia Gómez-Suaga
Dr. Estela Area Gomez
Guest Editors

Manuscript Submission Information

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Keywords

  • inter-organelle communication
  • membrane contact sites
  • organelle dynamics
  • mitochondria-associated membranes
  • cellular homeostasis

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Published Papers (1 paper)

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Review

19 pages, 1280 KiB  
Review
Nuclear Structure, Size Regulation, and Role in Cell Migration
by Yuhao Li, Shanghao Ge, Jiayi Liu, Deseng Sun, Yang Xi and Pan Chen
Cells 2024, 13(24), 2130; https://doi.org/10.3390/cells13242130 - 23 Dec 2024
Viewed by 1162
Abstract
The nucleus serves as a pivotal regulatory and control hub in the cell, governing numerous aspects of cellular functions, including DNA replication, transcription, and RNA processing. Therefore, any deviations in nuclear morphology, structure, or organization can strongly affect cellular activities. In this review, [...] Read more.
The nucleus serves as a pivotal regulatory and control hub in the cell, governing numerous aspects of cellular functions, including DNA replication, transcription, and RNA processing. Therefore, any deviations in nuclear morphology, structure, or organization can strongly affect cellular activities. In this review, we provide an updated perspective on the structure and function of nuclear components, focusing on the linker of nucleoskeleton and cytoskeleton complex, the nuclear envelope, the nuclear lamina, and chromatin. Additionally, nuclear size should be considered a fundamental parameter for the cellular state. Its regulation is tightly linked to environmental changes, development, and various diseases, including cancer. Hence, we also provide a concise overview of different mechanisms by which nuclear size is determined, the emerging role of the nucleus as a mechanical sensor, and the implications of altered nuclear morphology on the physiology of diseased cells. Full article
(This article belongs to the Special Issue Organelle Contact and Its Physiological Implications)
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