Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 766

Special Issue Editors


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Team "Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism", Université de Bourgogne, 21000 Dijon, France
Interests: lipids; oxysterols; fatty acids; polyphenols; oils; oxidation; inflammation; mitochondria; peroxisomes; lysosomes; apoptosis; autophagy; natural products; synthethic molecules; biomarkers; neurodegeneration; neurodegenerative diseases; aging; age-related diseases; nanoparticles; targeted therapy
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Team U1093 CAPS “Cognition, Action and Sensorimotor Plasticity”, Université de Bourgogne, 21000 Dijon, France
Interests: Alzheimer’s disease; frailty; aging process; epidemiology; successful aging
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Equipe 5, Neurobiologie des Comportements Alimentaires/Neurobiology of Feeding Behaviours 9E, Boulevard Jeanne d'Arc, 21000 Dijon, France
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
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Lab-NAFS ‘Nutritio—Functional Food & Vascular Health’, Faculty of Medicine, LR12ES05, University Monastir, Monastir 5000, Tunisia
Interests: aging; geriatrics; frailty; sarcopenia; Alzheimer’s disease; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This is the second edition of “Understanding Aging Mechanisms to Prevent Age-Related Diseases” that previously published ten papers.

During recent decades, the percentage of people over 65 years old, as well as the lifespan, has increased considerably and is expected to increase further in the coming years. Aging in good health has, therefore, become a societal and economic issue. Therefore, understanding the mechanisms of aging and preventing it by opposing the onset of age-related diseases are public health issues. In this context, it is important to identify the genetic and epigenetic factors that can influence aging and to determine the associated mechanisms. It is now crucial to determine strategies that slow down aging in order to oppose the onset of age-related diseases. Identifying predictive biomarkers of age-related diseases is a major challenge, as is the discovery of molecules that can oppose aging and the occurrence of associated diseases. This Special Issue of Cells, entitled 'Understanding Aging Mechanisms to Prevent Age-Related Diseases', aims to bring together relevant research studies dealing with cellular, molecular, pharmacological, and nutritional aspects of aging and age-related diseases. We look forward to your submissions.

Dr. Gérard Lizard
Prof. Dr. Pierre Jouanny
Dr. Anne Vejux
Prof. Dr. Sonia Hammami
Guest Editors

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Keywords

  • aging
  • age-related diseases
  • pathophysiology
  • cell mechanisms
  • therapies
  • biomarkers

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Published Papers (1 paper)

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Review

22 pages, 925 KiB  
Review
The Emerging Role of Water Loss in Dog Aging
by Gabriella Guelfi, Camilla Capaccia, Vicente Francisco Ratto, Antonello Bufalari, Leonardo Leonardi, Luca Mechelli, Simone Cenci and Margherita Maranesi
Cells 2025, 14(7), 545; https://doi.org/10.3390/cells14070545 - 4 Apr 2025
Viewed by 657
Abstract
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores the emerging role of water loss as a central and underestimated driver of functional decline in aging, with a focus [...] Read more.
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores the emerging role of water loss as a central and underestimated driver of functional decline in aging, with a focus on the dog, both as a clinically relevant target species and as a model for human aging. Age-related alterations in water metabolism—driven by changes in body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, and impaired urine concentration—lead to intracellular and extracellular dehydration, exacerbating functional decline. We examine molecular mechanisms of water regulation involving AQPs and osmolytes, and describe how dehydration contributes to structural and metabolic dysfunction across key biological compartments, including the kidney, brain, bone, and skeletal muscle. Physiological dehydration, a hallmark of aging, intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight how water loss impairs solvent capacity, solute transport, protein conformation, and cellular communication. Despite the known role of macronutrients in geriatric nutrition, hydration remains an often-overlooked factor in aging management. We argue for its inclusion as a fourth pillar in the nutritional approach to veterinary geriatrics, alongside protein, fat, and fiber. By investigating aging-associated water loss in dogs—species that share environments and lifestyle patterns with humans—we propose hydration-centered strategies to promote healthy aging in both veterinary and comparative medicine. Full article
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