Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
10.5
5.2
Journals
Cells
Special Issues
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
share announcement

Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 3963

Special Issue Editors

Dr. Gérard Lizard

E-Mail Website
Guest Editor
Team "Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism", Université de Bourgogne, 21000 Dijon, France
Interests: lipids; oxysterols; fatty acids; polyphenols; oils; oxidation; inflammation; mitochondria; peroxisomes; lysosomes; apoptosis; autophagy; natural products; synthethic molecules; biomarkers; neurodegeneration; neurodegenerative diseases; aging; age-related diseases; nanoparticles; targeted therapy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pierre Jouanny

E-Mail Website
Guest Editor
Team U1093 CAPS “Cognition, Action and Sensorimotor Plasticity”, Université de Bourgogne, 21000 Dijon, France
Interests: Alzheimer’s disease; frailty; aging process; epidemiology; successful aging
Special Issues, Collections and Topics in MDPI journals
Dr. Anne Vejux

E-Mail Website
Guest Editor
Equipe 5, Neurobiologie des Comportements Alimentaires/Neurobiology of Feeding Behaviours 9E, Boulevard Jeanne d'Arc, 21000 Dijon, France
Interests: oxysterols; very-long-chain fatty acids; lipid metabolism; diet; peroxisomes; biotherapies; inflammation; cancer; cell cycle and apoptosis; autophagy; biological membranes; oxidative damage; biomarkers; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sonia Hammami

E-Mail Website
Guest Editor
Lab-NAFS ‘Nutritio—Functional Food & Vascular Health’, Faculty of Medicine, LR12ES05, University Monastir, Monastir 5000, Tunisia
Interests: aging; geriatrics; frailty; sarcopenia; Alzheimer’s disease; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

This is the second edition of “Understanding Aging Mechanisms to Prevent Age-Related Diseases” that previously published ten papers.

During recent decades, the percentage of people over 65 years old, as well as the lifespan, has increased considerably and is expected to increase further in the coming years. Aging in good health has, therefore, become a societal and economic issue. Therefore, understanding the mechanisms of aging and preventing it by opposing the onset of age-related diseases are public health issues. In this context, it is important to identify the genetic and epigenetic factors that can influence aging and to determine the associated mechanisms. It is now crucial to determine strategies that slow down aging in order to oppose the onset of age-related diseases. Identifying predictive biomarkers of age-related diseases is a major challenge, as is the discovery of molecules that can oppose aging and the occurrence of associated diseases. This Special Issue of Cells, entitled 'Understanding Aging Mechanisms to Prevent Age-Related Diseases', aims to bring together relevant research studies dealing with cellular, molecular, pharmacological, and nutritional aspects of aging and age-related diseases. We look forward to your submissions.

Dr. Gérard Lizard
Prof. Dr. Pierre Jouanny
Dr. Anne Vejux
Prof. Dr. Sonia Hammami
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • age-related diseases
  • pathophysiology
  • cell mechanisms
  • therapies
  • biomarkers

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

31 pages, 1151 KB  
Review
Aging and Corneal Nerve Health: Mechanisms of Degeneration and Emerging Therapies for the Cornea
by Hanieh Niktinat, Melinda Alviar, Marziyeh Kashani, Hamed Massoumi, Ali R. Djalilian and Elmira Jalilian
Cells 2025, 14(21), 1730; https://doi.org/10.3390/cells14211730 - 4 Nov 2025
Viewed by 935
Abstract
Corneal nerves play a crucial role in maintaining ocular surface homeostasis by supporting the functional integrity of corneal epithelial, stromal, and endothelial cells; modulating tear secretion; and facilitating sensory responses essential for overall ocular health. With advancing age, these highly specialized peripheral sensory [...] Read more.
Corneal nerves play a crucial role in maintaining ocular surface homeostasis by supporting the functional integrity of corneal epithelial, stromal, and endothelial cells; modulating tear secretion; and facilitating sensory responses essential for overall ocular health. With advancing age, these highly specialized peripheral sensory fibers undergo progressive attrition and morphologic distortion driven by the canonical hallmarks of aging including genomic instability, impaired proteostasis, mitochondrial dysfunction, and chronic low-grade inflammation. The resulting neuro-immune dysregulation reduces trophic support, delays wound healing, and predisposes older adults to dry-eye disease, neurotrophic keratopathy, and postsurgical hypoesthesia. Age-exacerbating cofactors including diabetes, dyslipidemia, neurodegenerative disorders, topical preservatives, chronic contact-lens wear, herpes zoster ophthalmicus, and ocular-surface hypoxia further accelerate sub-basal nerve rarefaction and functional decline. This review provides an overview of age-related physiological alterations in ocular surface nerves, with a particular emphasis on corneal innervation. It also discusses risk factors that speed up these changes. Given the inherently limited regenerative capacity of corneal nerves and their inability to fully restore to baseline conditions following injury or degeneration, it is critical to identify and develop effective strategies aimed at mitigating or delaying physiological nerve degeneration and promoting nerve regeneration. This review also brings up emerging therapeutic strategies, including regenerative medicine, neuroprotective agents, and lifestyle interventions aimed at mitigating age-related corneal nerve degeneration. Full article
(This article belongs to the Special Issue Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition)
►▼ Show Figures

Figure 1

22 pages, 925 KB  
Review
The Emerging Role of Water Loss in Dog Aging
by Gabriella Guelfi, Camilla Capaccia, Vicente Francisco Ratto, Antonello Bufalari, Leonardo Leonardi, Luca Mechelli, Simone Cenci and Margherita Maranesi
Cells 2025, 14(7), 545; https://doi.org/10.3390/cells14070545 - 4 Apr 2025
Cited by 2 | Viewed by 2648
Abstract
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores the emerging role of water loss as a central and underestimated driver of functional decline in aging, with a focus [...] Read more.
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores the emerging role of water loss as a central and underestimated driver of functional decline in aging, with a focus on the dog, both as a clinically relevant target species and as a model for human aging. Age-related alterations in water metabolism—driven by changes in body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, and impaired urine concentration—lead to intracellular and extracellular dehydration, exacerbating functional decline. We examine molecular mechanisms of water regulation involving AQPs and osmolytes, and describe how dehydration contributes to structural and metabolic dysfunction across key biological compartments, including the kidney, brain, bone, and skeletal muscle. Physiological dehydration, a hallmark of aging, intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight how water loss impairs solvent capacity, solute transport, protein conformation, and cellular communication. Despite the known role of macronutrients in geriatric nutrition, hydration remains an often-overlooked factor in aging management. We argue for its inclusion as a fourth pillar in the nutritional approach to veterinary geriatrics, alongside protein, fat, and fiber. By investigating aging-associated water loss in dogs—species that share environments and lifestyle patterns with humans—we propose hydration-centered strategies to promote healthy aging in both veterinary and comparative medicine. Full article
(This article belongs to the Special Issue Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop