Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Signaling and Mechanism on Vascular Remodeling
edited by Ki Ho Park and Yitao Huang
submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Exploiting Stem Cell Pathways for Immune Protection
edited by
submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open
Keywords: stem cell; immune tolerance; immune modulation; autoimmunity; immunosuppression; immunotherapy; immune escape; immune evasion; immune privilege; stemness
Lipoprotein and Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanism of Endocrine Therapy Resistance in Breast Cancer
edited by and Clodia Osipo
submission deadline 1 May 2026 | Viewed by 76 | Submission Open
Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings
(This special issue belongs to the Section Cellular Pathology)
Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling
edited by Joaquim Gea Guiral
submission deadline 10 May 2026 | 2 articles | Viewed by 2205 | Submission Open
Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 10 May 2026 | Viewed by 598 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer
edited by , Lin Yuan and Yang Yu
submission deadline 10 May 2026 | Viewed by 143 | Submission Open
Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2026 | 5 articles | Viewed by 12263 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 15 May 2026 | 3 articles | Viewed by 2877 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
Mechanisms and Therapies in Chronic Pain
edited by Nikesh Kunder and June Bryan I. de la Peña
submission deadline 15 May 2026 | 1 articles | Viewed by 1628 | Submission Open
Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management
(This special issue belongs to the Section Cellular Pathology)
Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
edited by and Hisao Moriya
submission deadline 15 May 2026 | 2 articles | Viewed by 1269 | Submission Open
Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 May 2026 | Viewed by 242 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
The Metabolic Interactions and Pathways in Cancers
edited by Mohamed Elgendy
submission deadline 15 May 2026 | Viewed by 209 | Submission Open
Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy
Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
edited by , Patricia L Sullivan and Jeremy J Reynolds
submission deadline 15 May 2026 | Viewed by 140 | Submission Open
Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 123 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
The Role of Light in Ocular Health and Disease
edited by Krisztina Valter, and
submission deadline 15 May 2026 | Viewed by 113 | Submission Open
Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics
Conditional Programming of Cells, Advanced Computational Methods, and Intelligent Systems in Prostate Cancer Research
edited by Ahmed Fadiel
submission deadline 15 May 2026 | Viewed by 80 | Submission Open
Keywords: prostate cancer; conditional programming; cellular reprogramming; computational biology; cell-state transitions; lineage plasticity; tumor microenvironment; ex vivo models; machine learning
Advances in Spermatogenesis—Second Edition
edited by and Changmin Niu
submission deadline 15 May 2026 | Viewed by 40 | Submission Open
Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular Advances in Prenatal Exposure to Environmental Toxicants submission deadline 20 May 2026 | 4 articles | Viewed by 13827 | Submission Open
Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 May 2026 | 7 articles | Viewed by 10505 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Recent Advances in the Study of Tau Protein
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 5167 | Submission Open
Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 May 2026 | 1 articles | Viewed by 3821 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 May 2026 | 3 articles | Viewed by 3306 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1819 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1625 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 20 May 2026 | Viewed by 323 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 20 May 2026 | Viewed by 251 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 May 2026 | Viewed by 176 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Pathology and Therapies in Brain Tumor
edited by Bachuchu Lal
submission deadline 20 May 2026 | Viewed by 105 | Submission Open
Keywords: brain tumor; gliomas; target treatment; pathogenesis; animal models
(This special issue belongs to the Section Cellular Pathology)
Stem Cell Secretome: Therapeutic Potential in Regenerative Medicine
edited by Emanuela Mari
submission deadline 20 May 2026 | Viewed by 105 | Submission Open
Keywords: paracrine factors and tissue regeneration; secretome conditioned by microenvironment or stimuli; extracellularvesicles vs. soluble fraction; formulations and delivery of the therapeutic secretome
(This special issue belongs to the Section Stem Cells)
Regulation of Iron Homeostasis
edited by
submission deadline 20 May 2026 | Viewed by 76 | Submission Open
Keywords: iron homeostasis; iron transport; iron storage; iron-containing proteins
Cellular and Molecular Basis of Sjögren’s Syndrome
edited by Muhammad Shahnawaz Soyfoo
submission deadline 20 May 2026 | Viewed by 47 | Submission Open
Keywords: Sjö gren disease; epithelial dysfunction; immune tolerance; autoimmunity
Molecular Pathogenesis of Ovarian Cancer and Therapeutic Strategies
edited by Jayakumar R. Nair
submission deadline 20 May 2026 | Viewed by 46 | Submission Open
Keywords: ovarian cancer; pathogenic mutations; target therapy; genetic heterogeneity                                 
(This special issue belongs to the Section Cellular Pathology)
Non-Coding and Coding RNAs in Targeted Cancer Therapy submission deadline 25 May 2026 | 4 articles | Viewed by 8551 | Submission Open
Keywords: gene expression; non-coding RNAs; lncRNAs; microRNAs; piwi-associated RNA; circular RNAs; therapeutic targets
(This special issue belongs to the Section Cell and Gene Therapy)
Small Molecular Therapeutics Promoting Neuronal Plasticity, Hippocampal Learning, and Memory
edited by
submission deadline 25 May 2026 | 2 articles | Viewed by 5364 | Submission Open
Keywords: synaptic transmission; dendritic spines; metabotropic calcium influx; dendritic morphogenesis; small molecular therapeutics promoting neuronal plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 25 May 2026 | 2 articles | Viewed by 3871 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
Recent Advances in Astrocyte Neuron Communication submission deadline 25 May 2026 | Viewed by 999 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Cell Therapy for Retinal Diseases submission deadline 25 May 2026 | Viewed by 410 | Submission Open
Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration
(This special issue belongs to the Section Tissues and Organs)
Cell Signaling in Neurodegenerative Disease
edited by , Yasuhiro Funahashi, , and Md-nadim Hossain
submission deadline 25 May 2026 | Viewed by 348 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury
edited by and Angela R. Filous
submission deadline 25 May 2026 | Viewed by 159 | Submission Open
Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia
Cellular and Molecular Insights into Female Reproductive Biology
edited by
submission deadline 25 May 2026 | Viewed by 142 | Submission Open
Keywords: female reproductive biology; cellular mechanisms; reproductive aging; microfluidics; fertility preservation; stem cells; uterine endocrinology; infertility; reproductive health; gametogenesis
(This special issue belongs to the Section Reproductive Cells and Development)
Metabolic Regulation of Cell Behavior and Implications for Aging
edited by and José Antonio Rodríguez Navarro
submission deadline 25 May 2026 | Viewed by 113 | Submission Open
Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy
Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 25 May 2026 | Viewed by 81 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
Resistance of Hematological Malignancies and Solid Tumors to CAR T Cell Therapy
edited by
submission deadline 25 May 2026 | Viewed by 64 | Submission Open
Keywords: solid tumors; hematological malignancies; CAR T cell; immunotherapy; resistance; apoptosis
Human DNA Replication/Repair Factors submission deadline 25 May 2026 | Viewed by 52 | Submission Open
Keywords: DNA replication; replisome; DNA polymerase; helicase; replication fork; DNA repair; replication stress; DNA damage response; homologous recombination; replication-coupled DNA repair
From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring Therapeutic Strategies submission deadline 29 May 2026 | Viewed by 253 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 30 May 2026 | 2 articles | Viewed by 2213 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
(This special issue belongs to the Section Cellular Neuroscience)
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