Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of T Cells in Immune Disease Treatment
edited by
submission deadline 25 Dec 2025 | Viewed by 120 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells
(This special issue belongs to the Section Cellular Immunology)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 26 Dec 2025 | Viewed by 340 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1564 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cells of the Nervous System)
Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights
edited by and
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5162 | Submission Open
Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy
(This special issue belongs to the Section Tissues and Organs)
Fertility Disorders in Testes and Ovaries
edited by and Joanna Kochan
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1146 | Submission Open
Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 30 Dec 2025 | Viewed by 737 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Emerging Roles of Glial Cells in Human Health and Disease submission deadline 31 Dec 2025 | 10 articles | Viewed by 41681 | Submission Open
Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia
(This special issue belongs to the Section Cells of the Nervous System)
Gene Therapy for Rare Diseases
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 35852 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 24961 | Submission Open
(This special issue belongs to the Section Cells of the Nervous System)
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 31 Dec 2025 | 6 articles | Viewed by 18187 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biological Mechanisms in the Treatment of Neuropsychiatric Diseases
edited by Randall D Marshall and Frank S. Menniti
submission deadline 31 Dec 2025 | 6 articles | Viewed by 15029 | Submission Open
Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments
(This special issue belongs to the Section Cellular Pathology)
Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction
edited by Zhengui Zheng, and Liang Ma
submission deadline 31 Dec 2025 | 7 articles | Viewed by 13940 | Submission Open
Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 11414 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 10654 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise submission deadline 31 Dec 2025 | 2 articles | Viewed by 8609 | Submission Open
Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia
(This special issue belongs to the Section Tissues and Organs)
Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7724 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 3 articles | Viewed by 7604 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7373 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7220 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 6426 | Submission Open
Keywords: cell biology; physiology; molecular biology
Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience
edited by Howard Prentice and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6421 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cells of the Nervous System)
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | 2 articles | Viewed by 6155 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5682 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5166 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4176 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 4139 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3587 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3578 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | 1 articles | Viewed by 2678 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2400 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Dec 2025 | 4 articles | Viewed by 2181 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2106 | Submission Open
Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites
(This special issue belongs to the Section Cells of the Nervous System)
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2091 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2042 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1723 | Submission Open
Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity
(This special issue belongs to the Section Cellular Immunology)
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 1694 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1556 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1248 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1079 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
Colorectal Cancer: Molecular Mechanisms and Treatment Progress
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 875 | Submission Open
Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine
(This special issue belongs to the Section Tissues and Organs)
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 557 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Epigenetic Mechanisms and Aging
edited by
submission deadline 31 Dec 2025 | Viewed by 464 | Submission Open
Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses
(This special issue belongs to the Section Cellular Aging)
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 270 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
How Does Gene Regulation Affect Cancer Development? submission deadline 31 Dec 2025 | Viewed by 265 | Submission Open
Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs
(This special issue belongs to the Section Cell Microenvironment)
Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 31 Dec 2025 | Viewed by 252 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
Immunology and Immune Therapies for Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 175 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology
(This special issue belongs to the Section Cell Microenvironment)
Hematopoietic Cell Lines as Models for Leukemia and Lymphoma
edited by Stefan Nagel
submission deadline 31 Dec 2025 | Viewed by 157 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 31 Dec 2025 | Viewed by 157 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 154 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Traumatic Injury and Resolution submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open
Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics
(This special issue belongs to the Section Cellular Pathology)
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