Cellular and Molecular Mechanisms of Traumatic Injury and Resolution

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 34

Special Issue Editors


E-Mail Website
Guest Editor
1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
2. Pittsburgh Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: trauma immunology; molecular diagnostics and biomarkers; drug development
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Interests: precision medicine; computational biology; applications of intelligent systems in critical care

Special Issue Information

Dear Colleagues,

Traumatic injury is a leading cause of death and disability worldwide, yet its cellular and molecular underpinnings remain partially understood. Tissue disruption triggers a cascade of biomechanical forces, sterile inflammation, immunometabolism reprogramming, endothelial and coagulation abnormalities, and cell‑death pathways that evolve over minutes to weeks. Advances, such as single-cell, spatial, and multi-omics data integration, high-resolution imaging, and sophisticated in vitro and in vivo models, now allow unprecedented insight into these events.

This Special Issue seeks original research articles, comprehensive reviews, and short perspectives that demonstrate molecular and cellular responses to traumatic insults across organ systems and injury mechanisms (blunt, penetrating, and poly‑trauma). Topics of interest include, but are not limited to, innate and adaptive immune signaling, neuroinflammation, immunometabolism, endothelial dysfunction, trauma‑induced coagulopathy, mitochondrial and metabolic perturbations, extracellular vesicle and danger‑associated molecular‑pattern signaling, epigenetic and transcriptomic re‑wiring, biomarker discovery, and pharmacologic or cell-based interventions aimed at modulating maladaptive processes. Contributions that leverage integrative techniques to propose translational pathways toward bedside diagnostics and therapeutics are especially welcome.

This collection will advance our understanding of trauma biology and accelerate the development of targeted solutions leading to improved patient outcomes after injury.

Dr. Upendra K. Kar
Dr. Hamed Moheimani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic injury-associated immunometabolism
  • trauma-induced coagulopathy
  • endothelial dysfunction
  • cell death pathways
  • extracellular vesicles
  • single-cell and spatial omics
  • multi-omics
  • damage-associated molecular patterns
  • biomarker discovery
  • precision therapeutics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers

This special issue is now open for submission.
Back to TopTop