Cellular and Molecular Mechanisms of Traumatic Injury and Resolution
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 34
Special Issue Editors
2. Pittsburgh Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: trauma immunology; molecular diagnostics and biomarkers; drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Traumatic injury is a leading cause of death and disability worldwide, yet its cellular and molecular underpinnings remain partially understood. Tissue disruption triggers a cascade of biomechanical forces, sterile inflammation, immunometabolism reprogramming, endothelial and coagulation abnormalities, and cell‑death pathways that evolve over minutes to weeks. Advances, such as single-cell, spatial, and multi-omics data integration, high-resolution imaging, and sophisticated in vitro and in vivo models, now allow unprecedented insight into these events.
This Special Issue seeks original research articles, comprehensive reviews, and short perspectives that demonstrate molecular and cellular responses to traumatic insults across organ systems and injury mechanisms (blunt, penetrating, and poly‑trauma). Topics of interest include, but are not limited to, innate and adaptive immune signaling, neuroinflammation, immunometabolism, endothelial dysfunction, trauma‑induced coagulopathy, mitochondrial and metabolic perturbations, extracellular vesicle and danger‑associated molecular‑pattern signaling, epigenetic and transcriptomic re‑wiring, biomarker discovery, and pharmacologic or cell-based interventions aimed at modulating maladaptive processes. Contributions that leverage integrative techniques to propose translational pathways toward bedside diagnostics and therapeutics are especially welcome.
This collection will advance our understanding of trauma biology and accelerate the development of targeted solutions leading to improved patient outcomes after injury.
Dr. Upendra K. Kar
Dr. Hamed Moheimani
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- traumatic injury-associated immunometabolism
- trauma-induced coagulopathy
- endothelial dysfunction
- cell death pathways
- extracellular vesicles
- single-cell and spatial omics
- multi-omics
- damage-associated molecular patterns
- biomarker discovery
- precision therapeutics
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