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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Apr 2026 | Viewed by 425 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

Cell Biology of the Eye: Development, Disorders, and Repair

edited by

Meha Kabra

Praveen Joseph Susaimanickam

and

Alessandra Micera

submission deadline 15 Apr 2026 | Viewed by 180 | Submission Open

Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update

edited by

Tommaso Neri

and

Erica Bazzan

submission deadline 15 Apr 2026 | Viewed by 168 | Submission Open

Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets

Cellular Metabolism and Hormonal Signaling in Colorectal Cancer: Biomarkers and Therapeutic Opportunities

edited by Jibran Sualeh Muhammad

submission deadline 15 Apr 2026 | Viewed by 146 | Submission Open

Keywords: colorectal cancer; metabolic reprogramming; gut microbiome– metabolite interactions; therapy resistance; hormonal signaling

Advances in Annexin Biology

edited by

Raffaella Belvedere

Antonello Petrella

and Nunzia Novizio

submission deadline 15 Apr 2026 | Viewed by 144 | Submission Open

Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets

Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases

edited by

Nikolaos Patikas

and Emmanouil Metzakopian

submission deadline 15 Apr 2026 | Viewed by 129 | Submission Open

Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction

Cellular and Molecular Mechanisms Studies of the Adrenal Gland

edited by Wen-Jun Shen,

Fredric B. Kraemer

and Salman Azhar

submission deadline 15 Apr 2026 | Viewed by 105 | Submission Open

Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’ s syndrome

Neurobiology of Sleep

edited by

Henna-Kaisa Wigren

submission deadline 15 Apr 2026 | Viewed by 79 | Submission Open

Keywords: sleep-wake regulation; neural circuits; glial biology; neurometabolism; sleep disorders; aging; neuropathology; astrocytes; GABAergic neurons

(This special issue belongs to the Section Cellular Neuroscience)

Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms

edited by

Daria A. Chudakova

and

Kazuyuki Kitatani

submission deadline 20 Apr 2026 | 11 articles | Viewed by 33622 | Submission Open

Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and

Alessandro Lavoro

submission deadline 20 Apr 2026 | 9 articles | Viewed by 24360 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 20 Apr 2026 | 2 articles | Viewed by 7905 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Chromosomal Instability in Health and Disease

edited by Anna V. Roschke

submission deadline 20 Apr 2026 | 3 articles | Viewed by 6714 | Submission Open

Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Sperm Biology and Reproductive Health—Second Edition

edited by

Yi-Xun Liu

and

Shou-Long Deng

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5023 | Submission Open

Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3182 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2113 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

pH Sensing, Signalling, and Regulation in Cellular Processes

edited by Maike Glitsch

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1159 | Submission Open

Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets

(This special issue belongs to the Section Cell Signaling)

Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer

edited by Giusi Alberti and

Celeste Caruso Bavisotto

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Apr 2026 | Viewed by 383 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

Mesenchymal Stem/Stromal Cell Therapies: Innovations in Regenerative Medicine and Translational Applications

edited by Giandomenico Amico and Paolo Elia Cappella

submission deadline 20 Apr 2026 | Viewed by 301 | Submission Open

Keywords: mesenchymal stem cells (MSCs); stromal cells; microvesicles; exosomes; extracellular vesicles (EVs); immunomodulatory properties; bone marrow; adipose tissue; Wharton’ s jelly; cord blood; placenta; amnion

(This special issue belongs to the Section Stem Cells)

Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System

edited by Emanuela Paldino

submission deadline 20 Apr 2026 | Viewed by 161 | Submission Open

Keywords: microglia; macrophages; neurological disorders

Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

edited by

Tijana Subotički

Olivera Mitrović Ajtić

and

Vladan P. Čokić

submission deadline 20 Apr 2026 | Viewed by 143 | Submission Open

Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Stress-Induced Acute Immune Activation and Its Biological Consequences

edited by Ana Cicvaric

submission deadline 20 Apr 2026 | Viewed by 137 | Submission Open

Keywords: stress-induced immune signaling; acute immune activation; innate immune cell activation; cytokine response; cellular stress responses; inflammation and homeostasis

Signalling Mechanisms Regulating Cardiac Fibroblast Function

edited by Haofei Wang and

Yanhan Dong

submission deadline 20 Apr 2026 | Viewed by 104 | Submission Open

Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting

Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses

edited by

Geeta Upadhyay

submission deadline 20 Apr 2026 | Viewed by 82 | Submission Open

Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis

edited by

Sooyeon Lee

and

Mingyao Liu

submission deadline 20 Apr 2026 | Viewed by 59 | Submission Open

Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial– mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence

New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

edited by

Yong-Xiao Wang

submission deadline 20 Apr 2026 | Viewed by 47 | Submission Open

Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling

Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders

edited by

Shaohua Qi

and

George Augustine

submission deadline 20 Apr 2026 | Viewed by 40 | Submission Open

Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy

(This special issue belongs to the Section Cellular Neuroscience)

Therapeutic Targets in Glioblastoma

edited by Candice Mazewski and

Frank Eckerdt

submission deadline 25 Apr 2026 | 5 articles | Viewed by 17330 | Submission Open

Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

(This special issue belongs to the Section Cellular Neuroscience)

Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance

edited by

Yang Xu

and Ramkrishna Mitra

submission deadline 25 Apr 2026 | 2 articles | Viewed by 3773 | Submission Open

Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations

(This special issue belongs to the Section Cellular Pathology)

Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis

edited by Alessandra Loda and

Paola Bagnoli

submission deadline 25 Apr 2026 | 1 articles | Viewed by 2869 | Submission Open

Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors

Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision

edited by

Luminita Paraoan

and Janet R. Sparrow

submission deadline 25 Apr 2026 | Viewed by 619 | Submission Open

Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration

(This special issue belongs to the Section Tissues and Organs)

Molecular and Cellular Insights into Platelet Function, 2nd Edition

edited by

Stepan Gambaryan

and

Mikhail A. Panteleev

submission deadline 25 Apr 2026 | 1 articles | Viewed by 417 | Submission Open

Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity

Stem Cells in Action: Unlocking the Potential of Next-Generation Therapies

edited by George G. Koliakos

submission deadline 25 Apr 2026 | Viewed by 93 | Submission Open

Keywords: stem cell biology; differentiation and niche interaction; secretome/extracellular vesicles; organoids and disease modeling; regenerative medicine and tissue repair; immunomodulation and antimicrobial function; cell-based therapies and cGMP translation; scaffold and biomaterial integration

(This special issue belongs to the Section Stem Cells)

Gene Editing Using Synthetic Nucleic Acids

edited by Debmalya Bhunia

submission deadline 25 Apr 2026 | Viewed by 68 | Submission Open

Keywords: gene editing; synthetic nucleic acids; genetic diseases; targeted gene therapy; antisense binding

(This special issue belongs to the Section Cell and Gene Therapy)

Unlocking the Secrets Behind Drug Resistance at the Cellular Level

edited by

Sara Ricardo

and

Cristina Pinto Ribeiro Xavier

submission deadline 30 Apr 2026 | 5 articles | Viewed by 19740 | Submission Open

Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance

(This special issue belongs to the Section Cellular Immunology)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Apr 2026 | 5 articles | Viewed by 11563 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Eosinophils and Their Role in Allergy and Related Diseases

edited by

Paige Lacy

submission deadline 30 Apr 2026 | 6 articles | Viewed by 9266 | Submission Open

Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release

(This special issue belongs to the Section Cellular Immunology)

Research on T Cells in Skin Inflammatory Disorders

edited by

Henry K. Wong

and Qing-Sheng Mi

submission deadline 30 Apr 2026 | 1 articles | Viewed by 7932 | Submission Open

Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma

(This special issue belongs to the Section Cellular Immunology)

Onco-Hematology and Immunotherapy

edited by

Jean Gabert

and Régis T. Costello

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6232 | Submission Open

Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas

(This special issue belongs to the Section Cellular Immunology)

Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition

edited by

Yutaka Hirose

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4043 | Submission Open

Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease

edited by Ki Ho Park

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3211 | Submission Open

Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Discoveries in Calcium Signaling-Related Neurological Disorders

edited by Matheus De Castro Fonseca

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3094 | Submission Open

Keywords: Ca2+ signaling; neurons; neurological disorders; intracellular signaling; synaptic dysfunction

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia

edited by

Mookon Song

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2748 | Submission Open

Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation

(This special issue belongs to the Section Cellular Pathology)

Immune Cells from Pluripotent Stem Cells

edited by

Eunju Kang

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2542 | Submission Open

Keywords: pluripotent stem cells; T cells; B cells; macrophages; natural killer (NK) cells; dendritic cells; megakaryocytes; platelets

(This special issue belongs to the Section Stem Cells)

Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management

edited by Luca Antonioli and

Clelia Di Salvo

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2540 | Submission Open

Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP

Pathogenesis and Novel Therapies in Epithelial Cancers

edited by Jung Wook Park and Sanjeevram Dhandapani

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2293 | Submission Open

Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor

(This special issue belongs to the Section Cellular Pathology)

Advancements in Cardiac Metabolism

edited by

Michael Dodd

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2221 | Submission Open

Keywords: cardiovascular disease; metabolism; fatty acids; heart failure; mitochondrial dysfunction

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Artificial Intelligence to the Rescue of Cancer Research

edited by

Asunción Espinosa-Sánchez

and

Amancio Carnero

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1624 | Submission Open

Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine

(This special issue belongs to the Section Cell Methods)

Telomere Maintenance and Metabolic Reprogramming in the Tumor Microenvironment

edited by

Ji-Yong Sung

and Jiyue Zhu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1369 | Submission Open

Keywords: telomere maintenance mechanisms (TMM); tumor microenvironment (TME); telomerase activation; alternative lengthening of telomeres (ALT); cancer metabolism; mitochondrial dysfunction; redox homeostasis; DNA damage response (DDR); epigenetic regulation; cancer therapeutics; senescence-associated secretory phenotypes (SASPs)

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms Underlying Inflammatory Pain

edited by

Luke A. Pattison

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1138 | Submission Open

Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions

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