Control of Gene Expression by Co-transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition

Dear Colleagues,

Cells properly change the transcriptome through the regulation of gene expression in response to cell proliferation, differentiation, and various extracellular signals. In eukaryotes, the expression of all protein-coding genes and many non-coding RNA (ncRNA) genes is transcribed by RNA polymerase II (Pol II). The Pol II-transcribed nascent RNAs undergo various processing and modifications to become mature and functional RNAs.

In the past two decades, increasing evidence has revealed that transcription is intimately coupled with RNA processing and chromatin regulation through extensive interaction networks. Therefore, understanding the molecular detail and the biological significance of these co-transcriptional processes is essential for deciphering gene control mechanisms in cell homeostasis, cell fate specification, and associated diseases. This Special Issue focuses on the regulation of gene expression by co-transcriptional processes such as transcription, RNA processing (5’capping, splicing, polyadenylation), RNA modification, RNA transport, RNA degradation, histone modification, and biomolecular condensates formation.

 The formats for submissions include original research articles, brief reports, reviews, opinions, and methodology reports.

Topics of this Special Issue include, but are not limited to:

• Coupling between transcription and RNA processing
• Transcription elongation
• RNA processing (5’capping, splicing, polyadenylation)
• RNA modification
• RNA transport
• Histone modification
• Diseases associated with dysregulation of co-transcriptional processes
• ncRNAs (lncRNA, siRNA, piRNA) interacting with nascent RNAs
• methods for detecting co-transcriptional processes

Dr. Yutaka Hirose
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gene transcription
• transcription elongation
• RNA processing
• RNA modification
• RNA transport
• lncRNA
• histone modification
• biomolecular condensates
• diseases associated with dysregulation of gene regulation