Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 September 2025 | Viewed by 670
Special Issue Editors
Interests: inflammation; immunology; immunopharmacology; inflammatory bowel diseases; purinergic system
Interests: inflammatory bowel diseases; purinergic receptors; intestinal epithelial barrier; enteric nervous system
Special Issue Information
Dear Colleagues,
The purinergic pathway plays a key role in the regulation of body homeostasis at a cellular level, being implicated in cellular proliferation, differentiation, death, and regeneration, as well as being known to be involved in more complex processes such as pain, inflammation, immune responses, and endothelial vasodilatation.
Therefore, the aberrant activation of this signaling is associated with the onset of several disorders, including chronic pain, epilepsy, Alzheimer's disease, cancer, diabetes, and cardiovascular dysfunctions.
This Special Issue aims to highlight recent advances in the functions of purinergic receptors (comprising both P1 and P2 receptors) in both physiological and pathological status, with a central focus on the underlying molecular mechanisms. We will delve into the possibility of modulating these receptors as an innovative therapeutic option to manage different pathological conditions, trying to elucidate the benefits and risks of this strategy by analyzing studies conducted on cell lines, animal models, and humans.
Dr. Luca Antonioli
Dr. Clelia Di Salvo
Guest Editors
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Keywords
- purinergic receptors
- purinergic signaling
- adenosine
- ATP
- ADP
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