Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Mar 2026 | Viewed by 100 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 31 Mar 2026 | 5 articles | Viewed by 26095 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 3 articles | Viewed by 14589 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 9455 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact submission deadline 31 Mar 2026 | 3 articles | Viewed by 9040 | Submission Open
Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Mar 2026 | 2 articles | Viewed by 6050 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Mar 2026 | 2 articles | Viewed by 5144 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 31 Mar 2026 | 3 articles | Viewed by 4489 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 31 Mar 2026 | 2 articles | Viewed by 4262 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
(This special issue belongs to the Section Cell Signaling)
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
edited by Yuxiang Xie and Jingqi Yan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 4229 | Submission Open
Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Cellular Neuroscience)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Mar 2026 | 4 articles | Viewed by 4030 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2874 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 31 Mar 2026 | 2 articles | Viewed by 2854 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 2620 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 31 Mar 2026 | 3 articles | Viewed by 2267 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1636 | Submission Open
Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors
(This special issue belongs to the Section Cellular Neuroscience)
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1565 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1549 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 31 Mar 2026 | 2 articles | Viewed by 1271 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival
edited by and Giulio Menegazzi
submission deadline 31 Mar 2026 | 1 articles | Viewed by 957 | Submission Open
Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration
edited by Mukund Srinivasan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 810 | Submission Open
Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress
Pediatric Liver Tumors: Molecular Mechanisms and Therapeutic Strategies submission deadline 31 Mar 2026 | 1 articles | Viewed by 438 | Submission Open
Keywords: hepatoblastoma; hepatocellular carcinoma; pediatric liver tumors; fibrolamellar carcinoma; Beck-with-Wiedmann syndrome; hereditary tyrosinemia; molecular mechanisms; therapeutic strategies
Cellular and Molecular Insights into Allergies and Allergic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 354 | Submission Open
Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 320 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Cellular and Molecular Insights into Gynecologic Tumors
edited by and
submission deadline 31 Mar 2026 | Viewed by 291 | Submission Open
Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 31 Mar 2026 | Viewed by 287 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics
edited by
submission deadline 31 Mar 2026 | Viewed by 264 | Submission Open
Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition submission deadline 31 Mar 2026 | Viewed by 236 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 31 Mar 2026 | Viewed by 236 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Mar 2026 | Viewed by 235 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
Therapeutic Targeting of MicroRNAs in Human Cancer
edited by
submission deadline 31 Mar 2026 | Viewed by 229 | Submission Open
Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies
(This special issue belongs to the Section Cell and Gene Therapy)
Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 220 | Submission Open
Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies
Molecular and Cellular Drivers of Parkinson's Disease
edited by and
submission deadline 31 Mar 2026 | Viewed by 217 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death
(This special issue belongs to the Section Cellular Neuroscience)
Neurodegenerative Diseases and Related Proteins
edited by Tian Liu
submission deadline 31 Mar 2026 | Viewed by 216 | Submission Open
Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation
Multi-Omics Technologies in Immunity Within Tumors submission deadline 31 Mar 2026 | Viewed by 203 | Submission Open
Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity
Advances in CAR Cell Therapies and Manufacturing
edited by William J. Kelly and Madhuresh C. Sumit
submission deadline 31 Mar 2026 | Viewed by 194 | Submission Open
Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines
Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine
edited by and Andrea Wittig
submission deadline 31 Mar 2026 | Viewed by 185 | Submission Open
Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers
GABAA Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms
edited by Tingwei Mu and Yajuan Wang
submission deadline 31 Mar 2026 | Viewed by 172 | Submission Open
Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms
Stem Cells and Endometrium
edited by Shiying Jin
submission deadline 31 Mar 2026 | Viewed by 166 | Submission Open
Keywords: stem cell; homeostasis; regeneration; endometrium
(This special issue belongs to the Section Stem Cells)
Next-Generation CAR-T Cell Therapy: From Bench to Bedside
edited by and
submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open
Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models
(This special issue belongs to the Section Cellular Immunology)
Cell Death and Apoptosis
edited by and
submission deadline 31 Mar 2026 | Viewed by 149 | Submission Open
Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms
(This special issue belongs to the Section Cellular Pathology)
Regulation of Ca2+ Signals in Human Disease
edited by Yandong Zhou
submission deadline 31 Mar 2026 | Viewed by 130 | Submission Open
Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets
(This special issue belongs to the Section Cell Signaling)
From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria
edited by Sonam Gurung
submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open
Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)
Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies
edited by and Daniela Yildiz
submission deadline 31 Mar 2026 | Viewed by 120 | Submission Open
Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing
Cellular and Molecular Mechanisms in Aging
edited by Michel Satya Naslavsky and Mateus Vidigal
submission deadline 1 Apr 2026 | 1 articles | Viewed by 1915 | Submission Open
Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly
(This special issue belongs to the Section Cellular Aging)
Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications
edited by , Shibo Wei and
submission deadline 1 Apr 2026 | Viewed by 189 | Submission Open
Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism
Evolution, Structure, and Functions of Apolipoproteins L
edited by Etienne Pays
submission deadline 10 Apr 2026 | 4 articles | Viewed by 8826 | Submission Open
Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation
Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases
edited by and Justyna Okarmus
submission deadline 10 Apr 2026 | 3 articles | Viewed by 7157 | Submission Open
Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Cellular Neuroscience)
Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances
edited by Tsung-Chieh Shih
submission deadline 10 Apr 2026 | 3 articles | Viewed by 5605 | Submission Open
Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins
(This special issue belongs to the Section Cellular Immunology)
New Tools to Address Old Challenges in Tolerogenic Cellular Therapies
edited by Konstantinos Mengrelis and
submission deadline 10 Apr 2026 | Viewed by 155 | Submission Open
Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation
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