Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 2600
Special Issue Editors
Interests: Parkinson’s disease pathogenesis; neurodegeneration; stem cells; dopaminergic differentiation; neurotrophic factors; neuroprotection; cell replacement therpy; bioimaging; regenerative medicin
Special Issues, Collections and Topics in MDPI journals
Interests: Parkinson’s disease pathogenesis; stem cells; dopaminergic differentiation; neurodegeneration; neuroprotection; neurotrophic factors; bioimaging; cell replacement therapy; regenerative medicine
Special Issue Information
Dear Colleagues,
In 2024, despite remarkable advancements in biomedical research, neurodegenerative disorders such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and Amyotrophic Lateral Sclerosis (ALS) remain challenging to treat effectively, and no cures exist. Conventional therapies have primarily focused on symptom management, but these approaches have not been able to stop or reverse disease progression. As our knowledge of the pathogenesis of these conditions increases, the need for novel and effective treatments becomes more urgent.
This Special Issue of Cells, titled "Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases", aims to present cutting-edge research and emerging therapeutic strategies that hold promise for modifying disease progression. We are particularly interested in highlighting advances in the following:
- Stem Cell Transplantation: utilizing stem cells to replace damaged neurons, support neural growth, and modulate immune responses;
- Immunotherapy: using the body's immune system to target and neutralize pathological proteins and reduce neuroinflammation;
- Gene Therapy: employing technologies such as CRISPR/Cas9 and viral vectors to correct genetic mutations and provide long-term solutions for genetic neurodegenerative diseases;
- Focused Ultrasound (FUS): using this non-invasive technique to enhance drug delivery to the brain by temporarily opening the blood–brain barrier for precise targeting;
- Neuroprotective Agents: developing small molecule drugs that protect neurons from damage by targeting pathways involved in oxidative stress, mitochondrial dysfunction, and protein misfolding.
This Special Issue seeks contributions from both basic and clinical researchers in the form of original research articles and comprehensive reviews. We invite you to contribute your research and look forward to receiving insightful manuscripts, as we aim to stimulate further research that could lead to breakthroughs in the treatment of neurodegenerative diseases.
Prof. Dr. Morten Meyer
Dr. Justyna Okarmus
Guest Editors
Manuscript Submission Information
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Keywords
- neurodegenerative diseases
- experimental treatments
- stem cell transplantation
- immunotherapy
- gene therapy
- focused ultrasound
- neuroprotective agents
- Parkinson's disease
- Alzheimer's disease
- Huntington’s disease
- amyotrophic lateral sclerosis
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