Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Cognitive Function and Dysfunction submission deadline 20 Dec 2025 | 2 articles | Viewed by 6479
Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy
(This special issue belongs to the Section Cellular Neuroscience)
Physiology of Telocytes
edited by and Mihail E. Hinescu
submission deadline 20 Dec 2025 | 1 articles | Viewed by 5167
Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Metabolic Hallmarks in Cancer
edited by , Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3741
Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions
(This special issue belongs to the Section Cellular Metabolism)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 Dec 2025 | Viewed by 352
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders
edited by
submission deadline 20 Dec 2025 | Viewed by 280
Keywords: development; neurological disease; cancer; genetic; epigenetic
Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions
edited by
submission deadline 20 Dec 2025 | Viewed by 224
Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function
Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids
edited by and Sylwia Orczewska-Dudek
submission deadline 20 Dec 2025 | Viewed by 194
Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress
Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies
edited by Xiangguo Shi
submission deadline 20 Dec 2025 | Viewed by 178
Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution
(This special issue belongs to the Section Cellular Pathology)
Clockwork Cells: Decoding the Language of Cell Cycle Regulators
edited by , Kyung-sang Lee, and
submission deadline 20 Dec 2025 | Viewed by 162
Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis
(This special issue belongs to the Section Cell Proliferation and Division)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 25 Dec 2025 | 1 articles | Viewed by 2663 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
(This special issue belongs to the Section Cell Microenvironment)
Advances in Molecular Genomics and Pathology of Cancers
edited by
submission deadline 25 Dec 2025 | 1 articles | Viewed by 441 | Submission Open
Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Role of T Cells in Immune Disease Treatment
edited by
submission deadline 25 Dec 2025 | Viewed by 144 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells
(This special issue belongs to the Section Cellular Immunology)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 26 Dec 2025 | Viewed by 384 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1884 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Fertility Disorders in Testes and Ovaries
edited by and Joanna Kochan
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1770 | Submission Open
Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 30 Dec 2025 | Viewed by 835 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Emerging Roles of Glial Cells in Human Health and Disease submission deadline 31 Dec 2025 | 10 articles | Viewed by 47357 | Submission Open
Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia
(This special issue belongs to the Section Cellular Neuroscience)
Gene Therapy for Rare Diseases
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 42350 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 26966 | Submission Open
(This special issue belongs to the Section Cellular Neuroscience)
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 31 Dec 2025 | 7 articles | Viewed by 20076 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biological Mechanisms in the Treatment of Neuropsychiatric Diseases
edited by Randall D Marshall and Frank S. Menniti
submission deadline 31 Dec 2025 | 7 articles | Viewed by 19002 | Submission Open
Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments
(This special issue belongs to the Section Cellular Pathology)
Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction
edited by Zhengui Zheng, and Liang Ma
submission deadline 31 Dec 2025 | 7 articles | Viewed by 15263 | Submission Open
Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation
(This special issue belongs to the Section Reproductive Cells and Development)
Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience
edited by Howard Prentice and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9909 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise submission deadline 31 Dec 2025 | 2 articles | Viewed by 9377 | Submission Open
Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 8709 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 8487 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 3 articles | Viewed by 8364 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 8264 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | 3 articles | Viewed by 8206 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 7997 | Submission Open
Keywords: cell biology; physiology; molecular biology
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7083 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5457 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 4717 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3304 | Submission Open
Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites
(This special issue belongs to the Section Cellular Neuroscience)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | 1 articles | Viewed by 2860 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2312 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2038 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1863 | Submission Open
Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity
(This special issue belongs to the Section Cellular Immunology)
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1387 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1292 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Colorectal Cancer: Molecular Mechanisms and Treatment Progress
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1096 | Submission Open
Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine
(This special issue belongs to the Section Tissues and Organs)
Epigenetic Mechanisms and Aging
edited by
submission deadline 31 Dec 2025 | Viewed by 488 | Submission Open
Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses
(This special issue belongs to the Section Cellular Aging)
How Does Gene Regulation Affect Cancer Development? submission deadline 31 Dec 2025 | Viewed by 289 | Submission Open
Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs
(This special issue belongs to the Section Cell Microenvironment)
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 289 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
Immunology and Immune Therapies for Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 190 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology
(This special issue belongs to the Section Cell Microenvironment)
Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities
edited by
submission deadline 31 Dec 2025 | Viewed by 175 | Submission Open
Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Cellular and Molecular Mechanisms of Traumatic Injury and Resolution submission deadline 31 Dec 2025 | Viewed by 173 | Submission Open
Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics
(This special issue belongs to the Section Cellular Pathology)
Kinin System in Health and Disease: Cellular and Molecular Perspectives
edited by Marcos Gregnani and Leonardo Martins
submission deadline 31 Dec 2025 | Viewed by 171 | Submission Open
Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways
(This special issue belongs to the Section Cellular Pathology)
Inflammation and Aging in Acute and Chronic Kidney Injury submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; inflammation; aging
(This special issue belongs to the Section Cellular Aging)
The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis
edited by
submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open
Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis
(This special issue belongs to the Section Cellular Pathology)
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