cancers-logo

Journal Browser

Journal Browser

Personalizing Head and Neck Cancer Care

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 17 July 2026 | Viewed by 3069

Special Issue Editors


E-Mail Website
Guest Editor
Department of Otorhinolaryngology—Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Interests: head and neck cancer; personalized treatment; shared decision making; prehabilitation; prediction; frailty; targeted therapy; surgery

E-Mail Website
Guest Editor
Department of Otorhinolaryngology—Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Interests: head and neck oncology; geriatric oncology; sarcopenia; health care pathway
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

An important development in head and neck cancer research lies in personalizing cancer care. Patients with head and neck cancer are at high risk of physical, functional, and psychosocial deterioration and are thus considered vulnerable. They are at high risk of malnutrition, are often sarcopenic, and are generally frailer than patients with other solid malignancies. Identifying frail patients suitable for complex treatments or requiring treatment adaptation is paramount. 

Prediction models and intervention trials aid us in shared decision-making and individualizing treatment. Shared decision-making models are rising in prominence and enable patients to play an active role in shaping their treatment plans. Models should not only address physical aspects of well-being but also functional aspects and overall and disease-specific quality of life. 

Advances in personalized treatment strategies include targeted therapies, immunotherapy, and adaptive radiation techniques, as well as prehabilitation programs addressing nutrition, physical exercise, and psychosocial interventions. 

Lastly, innovations in monitoring head and neck cancer help to personalize follow-up. Developments include tumor mutational burden and circulating tumor DNA, as well as the use of telecommunication and telemedicine. 

Dr. Inge Wegner
Dr. G. B. Halmos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • personalized treatment
  • targeted therapy
  • prehabilitation
  • quality of life

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Jump to: Other

14 pages, 605 KB  
Review
Lacrimal Sac Tumors: A Histotype-Driven Literature Review
by Luca Giovanni Locatello, Enrico Redolfi De Zan, Riccardo Marzolino, Leigh J. Sowerby, Anna Tarantini, Paolo Lanzetta and Cesare Miani
Cancers 2025, 17(22), 3718; https://doi.org/10.3390/cancers17223718 - 20 Nov 2025
Viewed by 1279
Abstract
Objectives: Because of their rarity, lacrimal sac tumors (LSTs) are challenging to diagnose and treat. We herein provide an overview of the recent literature. Methods: A scoping search of the Cochrane library, PubMed and Google Scholar database in the last 5 years was [...] Read more.
Objectives: Because of their rarity, lacrimal sac tumors (LSTs) are challenging to diagnose and treat. We herein provide an overview of the recent literature. Methods: A scoping search of the Cochrane library, PubMed and Google Scholar database in the last 5 years was conducted. Three independent reviewers extracted data, and the findings were summarized due to study heterogeneity. Results: A total of 55 articles were included. LST histology is diverse and there is no commonly accepted staging system. Recent discoveries in their biology are offering new treatment strategies but exclusive endoscopic resections remain feasible in only very limited cases of non-aggressive LSTs. Conclusion: LSTs require a high index of suspicion because of their rarity. A histotype-driven treatment plan must be carefully prepared, but complete excision remains the cornerstone of treatment in all cases. Full article
(This article belongs to the Special Issue Personalizing Head and Neck Cancer Care)
Show Figures

Figure 1

Other

Jump to: Review

17 pages, 3652 KB  
Systematic Review
Prognostic Impact of MYC/TP63 Molecular Subtypes in Adenoid Cystic Carcinoma: A Meta-Analysis
by Karthik N. Rao, Prajwal Dange, M. P. Sreeram, Andrés Coca-Pelaz, Göran Stenman, Renata Ferrarotto, Teertha Shetty, Abbas Agaimy and Alfio Ferlito
Cancers 2026, 18(9), 1426; https://doi.org/10.3390/cancers18091426 - 29 Apr 2026
Viewed by 507
Abstract
Background: Adenoid cystic carcinoma (ACC) demonstrates marked clinical heterogeneity that is inadequately explained by conventional histopathologic and staging systems alone. Recent studies have identified two molecular subtypes based on transcriptomic profiling and MYC/TP63 expression (ACC I: MYC-high/TP63-low; ACC II: MYC-low/TP63-high) with potential prognostic [...] Read more.
Background: Adenoid cystic carcinoma (ACC) demonstrates marked clinical heterogeneity that is inadequately explained by conventional histopathologic and staging systems alone. Recent studies have identified two molecular subtypes based on transcriptomic profiling and MYC/TP63 expression (ACC I: MYC-high/TP63-low; ACC II: MYC-low/TP63-high) with potential prognostic significance. However, the magnitude and consistency of their survival impact remain uncertain. Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. PubMed, Embase, and PubMed Central were searched through January 2026 for studies reporting overall survival in ACC stratified by MYC/TP63 molecular subtype. Hazard ratios (HRs) were pooled using random-effects models. Heterogeneity, subgroup analyses by classification method, sensitivity analyses, cumulative meta-analysis, influence diagnostics, and publication bias assessment were performed. Results: Five independent cohorts from two publications comprising 247 patients (90 ACC I, 157 ACC II) were included. ACC I was associated with significantly worse overall survival compared with ACC II, with a pooled HR of 3.88 (95% CI: 2.55–5.90; p < 0.001). No statistical heterogeneity was observed (I2 = 0%). Prognostic separation was consistent across RNA sequencing and immunohistochemistry-based classification methods. Conclusions: Transcriptomic and MYC/TP63-based molecular subtyping provides strong and reproducible prognostic stratification in ACC. ACC I tumors confer an approximately four-fold higher mortality risk compared with ACC II tumors. Incorporation of molecular subtype into routine diagnostic and clinical decision-making may improve risk stratification, surveillance strategies, and future trial design in ACC. Full article
(This article belongs to the Special Issue Personalizing Head and Neck Cancer Care)
Show Figures

Figure 1

18 pages, 1863 KB  
Systematic Review
The Effect of Tumor Location and Extension on Survival in Patients with Sinonasal Mucosal Melanoma: A Systematic Review and Meta-Analysis
by Fan Yang, Marina Ruiz Cifuentes, Peter Horvatovich, Victor Guryev, Eszter Baltás, Gilles F H Diercks, Alienke van Pijkeren, Inge Wegner and Gyorgy B Halmos
Cancers 2025, 17(23), 3757; https://doi.org/10.3390/cancers17233757 - 25 Nov 2025
Cited by 1 | Viewed by 847
Abstract
Background/Objectives: SNMM is a rare and aggressive malignancy with a poor prognosis. The current staging systems fail to adequately stratify patient risk. This study aimed to evaluate the prognostic impact of tumor location and extension on overall survival (OS) in SNMM. Methods: A [...] Read more.
Background/Objectives: SNMM is a rare and aggressive malignancy with a poor prognosis. The current staging systems fail to adequately stratify patient risk. This study aimed to evaluate the prognostic impact of tumor location and extension on overall survival (OS) in SNMM. Methods: A systematic literature search of Medline, Web of Science, and Embase was performed to identify studies assessing the prognostic significance of tumor location and extension. Study quality was evaluated using the Quality in Prognosis Studies (QUIPS-2) tool. Meta-analyses were conducted to calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Eligible studies included primary SNMM reporting tumor location/extension and survival; observational designs (case series ≥ 5 patients) were eligible with no language restrictions. Searches covered MEDLINE, Web of Science, and Embase and were last updated on 10 Jan 2025; reference lists were also screened. Results: Thirty-four studies were included in the systematic review, of which ten met criteria for meta-analysis. Tumors located in the paranasal sinuses (HR = 2.89, 95% CI: 1.63–5.14) and those with orbital involvement (HR = 1.92, 95% CI: 1.34–2.73) were associated with significantly poorer OS. Maxillary and ethmoid sinus involvement showed no statistically significant difference compared with nasal cavity tumors. Conclusions: Tumor location and extension are significant prognostic indicators in SNMM. Patients with paranasal sinus tumors or orbital invasion have worse outcomes, supporting inclusion of these factors in future staging systems for better clinical decision-making. Limitations include the observational nature of the evidence, heterogeneity across definitions and analyses, and underpowered publication-bias tests; certainty of evidence was not formally graded. Full article
(This article belongs to the Special Issue Personalizing Head and Neck Cancer Care)
Show Figures

Graphical abstract

Back to TopTop