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Resection and Reconstruction for Breast Cancer

A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Clinical Research in Cancer".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 784

Editors


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Guest Editor
Department of Surgical Oncology, Regional Specialist Hospital, 59220 Legnica, Poland
Interests: breast cancer; surgery; breast reconstruction

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Guest Editor
Department of Gynecology, Hôpital Européen, Marseille, France
Interests: breast cancer; sentinel lymph node biopsy; breast reconstruction; robotic surgery; surgical oncology
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Special Issue Information

Dear Colleagues,

Breast cancer is the most common malignancy found in women; according to GLOBOCAN, there were nearly 2.3 million of new cases diagnosed in 2022 and 670,000 deaths, respectively. Therefore, early diagnosis through proper screening, oncologic vigilance and education across the globe and proper combined modality treatment are vital.

This also means that breast cancer is a curable disease and there is a vast number of survivors, with many living with various consequences following therapy.

Surgery is a cornerstone of combined modality treatment and cannot be omitted in any case. Oncoplastic surgery (Audretsch), the integration of plastic surgery techniques for reshaping of the breast immediately after cancer eradication, allows us to decrease the positive margin rate and to obtain better aesthetics, and thus a higher quality of life. Oncoplastic techniques allow us to decrease the breast deformity rate following wide excisions. Breast reconstruction, either immediate or secondary to mastectomy and either implant-based and using autologous tissues, allows us to avoid mutilation. Being the oldest method of cancer therapy, surgery is very dynamic and there have been many changes in surgical strategies and techniques in this field in the last few decades.

There are two pillars of successful treatment in oncology: survival and the quality of life. Both have been successfully improved by modern surgery of the breast in frames of combined modality treatment.

For this Special Issue of Cancers, we welcome manuscripts covering surgical treatment of this very special and numerous group of patients: women touched by breast cancer.

Dr. Radoslaw Tarkowski
Dr. Gilles Houvenaeghel
Guest Editors

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Keywords

  • oncoplastic breast surgery
  • breast reconstruction
  • breast cancer

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Published Papers (1 paper)

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Research

21 pages, 1575 KB  
Article
Continuous Topical Oxygen Therapy Is Associated with Accelerated Nipple–Areolar Complex Necrosis Healing Following Nipple-Sparing Mastectomy: A Propensity-Matched Three-Way Comparison
by Hyung-Suk Yi, Ho-Young Im, Jin-Hyung Park, Sung-Ui Jung, Jin-Hyuk Choi, Ku-Sang Kim and Yoon-Soo Kim
Cancers 2026, 18(12), 1907; https://doi.org/10.3390/cancers18121907 - 11 Jun 2026
Viewed by 399
Abstract
Background/Objectives: Nipple–areolar complex (NAC) necrosis following nipple-sparing mastectomy (NSM) delays adjuvant therapy and compromises oncological outcomes. This retrospective propensity-matched cohort study compared continuous topical oxygen therapy (cTOT), hyperbaric oxygen therapy (HBOT), and standard care (SOC) in patients with NAC necrosis after NSM. Methods: [...] Read more.
Background/Objectives: Nipple–areolar complex (NAC) necrosis following nipple-sparing mastectomy (NSM) delays adjuvant therapy and compromises oncological outcomes. This retrospective propensity-matched cohort study compared continuous topical oxygen therapy (cTOT), hyperbaric oxygen therapy (HBOT), and standard care (SOC) in patients with NAC necrosis after NSM. Methods: Between January 2020 and August 2025, 213 patients with NAC necrosis after NSM at a single academic center met eligibility criteria (cTOT, n = 57; HBOT, n = 59; SOC, n = 97). Propensity score matching (1:1:1, 15 covariates, all standardized mean differences < 0.1) yielded 57 matched triplets (171 patients). The primary outcome was time to complete epithelialization, with restricted mean survival time (RMST) at 56 days designated as a co-primary metric. Results: cTOT was associated with the fastest healing (mean 30.5 ± 9.9 days vs. HBOT 36.4 ± 9.0, p = 0.007, vs. SOC 45.1 ± 10.6, p < 0.001). RMST analysis demonstrated a mean gain of 14.0 unhealed days (95% CI, 10.5–17.5) for cTOT versus SOC. Eight-week healing rates were 98.2% (cTOT), 96.5% (HBOT), and 87.7% (SOC). Multivariable Cox regression identified cTOT as an independent predictor of accelerated healing (HR 4.61; 95% CI, 2.99–7.11; p < 0.001), with results stable across incision-type and ptosis-grade sensitivity analyses. The treatment association was most pronounced in larger wounds (≥2.0 cm2; HR 6.85; p for interaction = 0.018). cTOT patients also reported significantly lower pain and higher satisfaction, with no device-related discontinuations (0/57). Conclusions: cTOT was associated with significantly accelerated NAC necrosis healing and, as a portable home-based therapy, may support oncological treatment timelines after NSM. The shorter time to adjuvant initiation observed for cTOT (continuous outcome) was not paralleled by a significant reduction in the >6-week delay endpoint, which requires confirmation in multicenter randomized trials. Full article
(This article belongs to the Special Issue Resection and Reconstruction for Breast Cancer)
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