Advances in Pediatric Liver Cancer Research
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 52
Special Issue Editor
Interests: hepatoblastoma; malignant rhabdoid tumor; liver; liquid biopsy; metastasis
Special Issue Information
Dear Colleagues,
Over the last decade, our understanding of pediatric primary liver tumors—including hepatoblastoma, hepatocellular carcinoma, malignant rhabdoid tumor, and undifferentiated embryonal sarcoma—has advanced significantly. This progress is especially impressive given how rare these cancers are, even though they have the fastest rising incidence among all pediatric solid tumors. Most patients are treated with a combination of chemotherapy and surgery, either resection or transplant, with immunotherapy and radiotherapy also being used in some cases. While cure rates are generally high, outcomes remain poor for those with high-risk disease, highlighting the need for further research into more effective treatments. Key recent advancements include detailed molecular profiling to identify common genetic changes, disease drivers, and molecular signatures, as well as development and validation of new clinically relevant disease models such as patient-derived xenografts and cell lines.
This Special Issue of Cancers will focus on recent advances in pediatric liver cancer research. We hope to cover all pediatric primary tumors of the liver, including hepatoblastoma, hepatocellular carcinoma, malignant rhabdoid tumor, and undifferentiated embryonal sarcoma of the liver. The goal of this Special Issue is to provide a platform for colleagues who are pursuing new, groundbreaking studies aimed at elucidating pediatric liver cancer biology and developing new therapeutic strategies for these patients, as well as review articles that unify the field and highlight areas that still need to be addressed.
We warmly invite all colleagues to contribute original research articles and reviews to this Special Issue, and we look forward to receiving and reading your submissions.
Dr. Sarah E. Woodfield
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hepatoblastoma
- pediatric hepatocellular carcinoma
- fibrolamellar carcinoma
- malignant rhabdoid tumor
- undifferentiated embryonal sarcoma
- chemotherapy
- targeted therapy
- immunotherapy
- surgery
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