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Cancers
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Advances in Clinical Surgery for Gynecological Cancers
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Advances in Clinical Surgery for Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 2733

Editor

Dr. Sebastian Szubert

E-Mail Website
Guest Editor
Division of Gynaecological Oncology, Department of Gynaecology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Interests: ovarian cancer; endometrial cancer; cervical cancer; gynecological surgery

Special Issue Information

Dear Colleagues,

The surgical management of gynecological malignancies is a pressing issue. Recent progress in managing gynecological tumors has mainly been based on targeted therapies, allowing adequate surgical treatment for many patients and significantly increasing survival rates. Every year, many important studies are published, influencing the quality of care for patients with gynecological cancers.

Currently, researchers are focusing on several essential issues. One is the personalization of the resection range according to the molecular and clinical characteristics of the disease. Another key issue is the identification of frailty and comorbidity among cancer patients, to improve personalized perioperative care. In addition, further studies are needed on the organization of health care for patients undergoing extensive surgery, such as cytoreduction and pelvic exenteration.

This Special Issue will focus on all issues related to gynecological cancer surgery. It will also showcase the latest advances in developing effective strategies for preventing postoperative complications, improving patients' postoperative recovery and quality of life and the outcomes of gynecological surgery.   

For this Special Issue, we welcome the submission of original research articles and reviews. We look forward to receiving your contributions.

Dr. Sebastian Szubert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • gynecological surgery
  • gynecological oncology
  • reconstructive surgery
  • pelvic exenteration
  • supportive cancer care

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Published Papers (2 papers)

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Review

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19 pages, 609 KB  
Review
Preoperative PARP Inhibitors in Ovarian Cancer Trials: Connecting Molecular Oncology and Cytoreductive Surgery
by Cezary Miedziarek, Paweł Caputa, Hubert Bochyński, Mikołaj Piotr Zaborowski and Ewa Nowak-Markwitz
Cancers 2026, 18(13), 2157; https://doi.org/10.3390/cancers18132157 (registering DOI) - 5 Jul 2026
Abstract
Cytoreductive surgery remains one of the key treatment modalities in advanced ovarian cancer. Complete cytoreduction is the main surgical goal. PARP inhibitors are currently established mainly as maintenance therapy after response to platinum-based chemotherapy, particularly in patients with BRCA-mutated or homologous recombination-deficient [...] Read more.
Cytoreductive surgery remains one of the key treatment modalities in advanced ovarian cancer. Complete cytoreduction is the main surgical goal. PARP inhibitors are currently established mainly as maintenance therapy after response to platinum-based chemotherapy, particularly in patients with BRCA-mutated or homologous recombination-deficient tumors. Their use before cytoreductive surgery remains investigational. This review evaluates preoperative PARP inhibition from a surgical perspective. This narrative review summarizes current evidence, ongoing clinical trials, and perioperative considerations related to preoperative or neoadjuvant PARP inhibitor strategies in advanced ovarian cancer. Particular attention was given to the review of current clinical trials’ strategies, resectability, complete cytoreduction, patient selection, perioperative safety, treatment timing, and surgery-specific endpoints. Current studies explore several preoperative approaches, including short window-of-opportunity treatment before primary debulking surgery, PARP inhibitor monotherapy as potential conversion therapy in homologous recombination-deficient disease, PARP inhibitor-based strategies before interval debulking surgery, combination regimens with immunotherapy or antiangiogenic therapy, and preoperative PARP inhibitor use before secondary cytoreduction in recurrent disease. These studies suggest that preoperative PARP inhibition may provide biological and surgical insights, but available evidence remains preliminary. Key concerns include hematologic toxicity, surgical postponement, perioperative complications, wound healing, postoperative recovery, and the risk of delaying standard chemotherapy or surgery. Preoperative PARP inhibitor therapy is theoretically promising but an unproven strategy in ovarian cancer. Its future value will depend on prospective trials showing that it can safely improve resectability and complete cytoreduction without compromising treatment timing. Future studies should include surgery-specific endpoints in addition to conventional oncologic outcomes. Full article
(This article belongs to the Special Issue Advances in Clinical Surgery for Gynecological Cancers)
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Other

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30 pages, 2592 KB  
Systematic Review
Surgical Techniques for Radical Trachelectomy
by Sebastian Szubert, Magdalena Nadolna, Paweł Wawrzynowicz, Agnieszka Horała, Julia Kołodziejczyk, Łukasz Koberling, Paweł Caputa, Mikołaj Piotr Zaborowski and Ewa Nowak-Markwitz
Cancers 2025, 17(6), 985; https://doi.org/10.3390/cancers17060985 - 14 Mar 2025
Cited by 3 | Viewed by 2251
Abstract
Background/Objectives: The primary aim of this systematic review was to evaluate fertility outcomes and the oncological safety of different surgical techniques of radical trachelectomy (RT). Methods: The systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews [...] Read more.
Background/Objectives: The primary aim of this systematic review was to evaluate fertility outcomes and the oncological safety of different surgical techniques of radical trachelectomy (RT). Methods: The systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic literature search on PubMed, Embase, and Google Scholar was performed between 1 November 2023 and 31 March 2024 with no limits for the time of publication. Results: In total, 56 studies met the inclusion criteria: 22 for abdominal RT (1712 patients), 14 for endoscopic RT (445 patients), and 22 for vaginal RT (1158 patients). Data regarding certain steps of the procedure (uterine artery preservation, autonomous nerve-sparing, abdominal cerclage, types of sutures used for the cerclage, uterine dilatation during cerclage placement, prolongation of uterine catheterization, type of uterovaginal anastomosis, antibiotic prophylaxis, and suppression of menstruation) were extracted and analyzed with regard to the obstetrical and oncological outcomes. Endoscopic RT was associated with a significantly higher pregnancy rate and a lower rate of preterm deliveries. Uterine artery preservation was associated with a higher live birth rate. Nerve-sparing RT resulted in a higher pregnancy rate, but no differences in the attempt for pregnancy and live birth rates were observed. Conclusions: Taking into account the obstetrical outcomes, it seems that the preferred option for radical RT is an endoscopic procedure with preservation of the uterine artery and the pelvic autonomic nerves. However, the safety of the endoscopic approach should be evaluated in prospective trials. Full article
(This article belongs to the Special Issue Advances in Clinical Surgery for Gynecological Cancers)
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