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Cancers
Special Issues
Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions
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Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 10 October 2025 | Viewed by 504

Special Issue Editor

Dr. Apriliana Kartikasari

E-Mail Website
Guest Editor
School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC 3083, Australia
Interests: ovarian cancer; biomarkers; therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ovarian cancer is one of the deadliest cancers among women worldwide. Despite advances in treatment, the high rates of late-stage diagnosis and resistance to therapy result in low survival rates. This cancer is characterised by the uncontrolled growth of cells in the ovaries and is classified into several histological types, with high-grade serous carcinoma (HGSC) being the most common and aggressive form. Genetic mutations, epigenetic modifications, defective signalling pathways, cancer-promoting tumour microenvironment, immune evasion, and inflammation are known to contribute to ovarian cancer pathogenesis.

Understanding the mechanisms underlying ovarian cancer pathogenesis is critical for developing effective therapeutic strategies. Continued research into these mechanisms is essential for the identification of targeted therapies that can improve outcomes for ovarian cancer patients. Companion biomarkers/tests that predict response towards specific treatments could further help develop personalised treatment strategies.

We are pleased to invite you to participate in this Special Issue, which will focus on the latest findings regarding the mechanisms involved in ovarian cancer development, progression, and recurrence, the intervention/treatment approaches for ovarian cancer, and the companion biomarkers that could predict treatment outcomes. Original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Apriliana Kartikasari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ovarian cancer
  • pathogenesis
  • therapy
  • biomarkers
  • molecular

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Published Papers (1 paper)

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Research

15 pages, 631 KiB  
Article
Fertility-Sparing Surgery for Non-Epithelial Ovarian Malignancies: Ten-Year Retrospective Study of Oncological and Reproductive Outcomes
by Ivana Likic Ladjevic, Jelena Dotlic, Katarina Stefanovic, Branislav Milosevic, Aleksandra Beleslin, Olga Mihaljevic, Jovan Bila, Ivana Vukovic, Milos Radojevic and Zoran Vilendecic
Cancers 2025, 17(8), 1304; https://doi.org/10.3390/cancers17081304 - 12 Apr 2025
Viewed by 229
Abstract
Background/Objectives: Due to the rarity and histological heterogeneity of non-epithelial ovarian cancers (NEOCs), monitoring their reproductive and oncological outcomes is challenging. Therefore, this study aimed to investigate the oncological and reproductive outcomes of patients with NEOCs treated with fertility-sparing surgery over the past [...] Read more.
Background/Objectives: Due to the rarity and histological heterogeneity of non-epithelial ovarian cancers (NEOCs), monitoring their reproductive and oncological outcomes is challenging. Therefore, this study aimed to investigate the oncological and reproductive outcomes of patients with NEOCs treated with fertility-sparing surgery over the past 10 years at our tertiary referral university clinic. Methods: This retrospective study included all the NEOC patients diagnosed and treated with fertility-sparing surgery from 2010 to 2019. The patient demographic and clinical characteristics; data regarding the treatment andthe clinical, laboratory, and imaging findings during follow-up; and disease recurrences were recorded. In this study, the recurrence-free survival and the overall survival were the oncological outcomes. The reproductive outcomes were assessed as attempting and achieving pregnancy. Results: This study included 39 patients. The most frequent NEOCs were granulosa cell tumors (53.8%). The majority of the tumors were in the IA or IC1 stage. The initial therapy was generally a unilateral salpingo-oophorectomy (30.8%). Adjuvant chemotherapy was received by 48.7% of the patients. An NEOC recurrence was registered in 25.6% of the patients, mostly during the first two postoperative years. The recurrence-free survival was 76.92%. A regression analysis showed that amore advanced stage of NEOC was the most important predictor of disease recurrence. The overall survival rate was 87.2%, with a mean time to an adverse outcome of 23.01 +/−10.68 months. The regression analysis showed that better survival depended mostly on not having disease recurrence. After treatment, ten patients tried to conceive and seven succeeded. All the children were in good condition upon birth. Conclusions: Fertility-sparing treatment for NEOCs was proven as a safe and successful option in terms of both oncological and reproductive outcomes. Full article
(This article belongs to the Special Issue Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions)
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