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Cancers
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Clinicopathological Study of Gynecologic Cancer (2nd Edition)
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Clinicopathological Study of Gynecologic Cancer (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 683

Special Issue Editor

Dr. Massimo Origoni

E-Mail Website
Guest Editor
Department of Gynecology & Obstetrics, Vita Salute San Raffaele University School of Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Interests: cervical cancer; human papillomavirus; HPV; gynecologic oncology; preventive oncology; CIN; cervical intraepithelial neoplasia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecological malignancies are a critical global challenge; at present, high mortality rates due to the lack of early diagnosis are reported in many countries. In recent years, significant milestones have been achieved in terms of uncovering the biology and the natural history of neoplasms. For example, it is now known that understanding the mechanisms of human papillomavirus can aid in the diagnosis and curing of different histological subtypes of cervical cancer. Additionally, genetic alterations play an important causal role in the development and progression of endometrial and ovarian cancers, and environmental factors, such as the genital microbiome, further exacerbate them. Given these findings, both biological and clinical research has increasingly focused on the identification and validation of biomolecular, pathological, and omics parameters associated with the higher risk of cancer development in females; to an extent, such research has led to clinically relevant improvements in terms of persistence/recurrence rates and better survival rates. Therefore, in this Special Issue, we cordially invite submissions of original research and comprehensive review articles focusing on the promising results found in recent biological and clinical research that have the potential to improve clinical practice and patient treatment, thereby enhancing the management of female genital cancers.

Dr. Origoni Massimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological oncology
  • gynecological cancer
  • female cancer
  • uterine cancer
  • ovarian cancer
  • endometrial cancer
  • cancerogenesis
  • cancer biology
  • cell transformation
  • cancer pathology
  • cancer biology

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Published Papers (1 paper)

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Research

11 pages, 448 KiB  
Article
Sentinel Node Biopsy Using Two Concurrent Labeling Techniques (Radioactive Tracer With/Without Blue Dye vs. Indocyanin Green-ICG) in Early-Stage Endometrial Cancer Patients (TESLA–1): A Prospective Observational Study CEEGOG EX-02
by Maja Pakiz, David Cibula, Dariusz Grzegorz Wydra, Jaroslav Klat, Michal Zikan, Olga Matylevich, Renata Poncova, Anna Abacjew-Chmylko, Andrej Cokan, Martina Romanova, Filip Frühauf, Sambor Sawicki, Leyla Al Mahdawi, Roman Kocian, Zuzanna Mascianica, Jure Knez, Lukas Dostalek, Paulina Zygowska, Jiri Slama, Marek Murawski, Daniela Fischerova, Radoslaw Owczuk and Andraz Dovnikadd Show full author list remove Hide full author list
Cancers 2025, 17(10), 1606; https://doi.org/10.3390/cancers17101606 - 9 May 2025
Viewed by 415
Abstract
Background: While sentinel lymph node (SLN) biopsy has been integrated into international guidelines for endometrial cancer, a standardized technique is still lacking. This study addresses whether the concurrent use of two tracers, technetium-99 (Tc) and indocyanine green (ICG), administered intracervically through distinct techniques, [...] Read more.
Background: While sentinel lymph node (SLN) biopsy has been integrated into international guidelines for endometrial cancer, a standardized technique is still lacking. This study addresses whether the concurrent use of two tracers, technetium-99 (Tc) and indocyanine green (ICG), administered intracervically through distinct techniques, enhances the performance of SLN biopsies. As the blue dye is used routinely by some centers, it can be used alone; however, our analysis focused on only Tc and ICG (as is used in the majority of centers). Methods: A prospective multicentric observational study was designed to evaluate the unilateral detection rate, bilateral detection rates, sensitivity, and consistency of SLNs when using both tracers simultaneously in patients with early-stage endometrial cancer. Results: Our findings demonstrated that the simultaneous use of ICG and Tc significantly outperformed the use of either tracer alone. Unilateral detection rates were 69.2% for Tc, 84.9% for ICG, and 88.4% for both. Bilateral detection rates were 57.0% for Tc, 77.9% for ICG, and 83.6% for both. Additionally, the incidence of “empty pockets” was low with both tracers, at 2.7%. Notably, the concurrent application of both tracers identified instances where the Tc-labeled sentinel node differed from the ICG-labeled sentinel node. Conclusions: The combined use of Tc and ICG in SLN biopsy for early-stage endometrial cancer significantly enhances detection rates and reduces the occurrence of “empty pockets”, potentially decreasing the need for site-specific lymphadenectomy. Full article
(This article belongs to the Special Issue Clinicopathological Study of Gynecologic Cancer (2nd Edition))
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