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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Pathology of Lymphoma and Leukemia

edited by

Siba El Hussein

submission deadline 31 Mar 2026 | 6 articles | Viewed by 8402 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Colorectal Cancer Liver Metastases

edited by

Piero Boraschi

and

Francescamaria Donati

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7004 | Submission Open

Keywords: liver metastases; colorectal cancer; treatment; imaging; oncologic strategy

(This special issue belongs to the Section Cancer Metastasis)

Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies

edited by Marina Díaz-Beyá and Maria Queralt Salas

submission deadline 31 Mar 2026 | 4 articles | Viewed by 6661 | Submission Open

Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation

(This special issue belongs to the Section Transplant Oncology)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6330 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Treatment Approaches for AML

edited by

Semra Aydin

and

Raheel Iftikhar

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6308 | Submission Open

Keywords: AML treatment; allogeneic HSCT; novel targeted therapeutic agents; diagnostic; treatment strategies

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in Urothelial Carcinoma

edited by

Akinori Minato

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6086 | Submission Open

Keywords: bladder cancer; upper tract urothelial carcinoma; immune checkpoint inhibitors; tumor microenvironment; biomarkers for immunotherapy; combination therapy; neo-adjuvant/adjuvant immunotherapy; resistance mechanisms; novel immunotherapeutic approaches; personalized medicine

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Renal Cell Carcinoma

edited by Philipp Ivanyi and Hendrik Eggers

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5879 | Submission Open

Keywords: renal cell carcinoma; treatment; metastatic; prediction; medical treatment; immunotherapy; multimodal therapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Significance of KRAS Gene Mutations in Colorectal Cancer (2nd Edition)

edited by

Grazia Palomba

and

Maria Cristina Sini

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5000 | Submission Open

Keywords: KRAS; colorectal cancer; target therapy; mechanism; treatment targets

(This special issue belongs to the Section Molecular Cancer Biology)

The Oral Microbiome and Its Link to Oral Cancer: Exploring the Role of Infectious Agents

edited by

Tomoaki Shintani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4497 | Submission Open

Keywords: oral microbiome; oral cancer; infectious agents; microbial dysbiosis; host– microbe interactions

(This special issue belongs to the Section Infectious Agents and Cancer)

Mastering the Immunosuppressive Tumor Microenvironment with Cancer Vaccines

edited by

Prem Prakash Kushwaha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4227 | Submission Open

Keywords: tumor microenvironment; cancer vaccines; immunosuppression; immune modulation; checkpoint inhibitors; dendritic cell vaccines; T cell activation; personalized cancer immunotherapy; vaccine adjuvants; combination immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer

edited by

Greta Alì

and

Maria Giovanna Mastromarino

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4164 | Submission Open

Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3729 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Cancer Drug Discovery and Development: 2nd Edition

edited by Gary Piazza

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3437 | Submission Open

Keywords: signal transduction inhibitors; small-molecule inhibitors; antibodies; PROTOC; immunotherapy; medicinal chemistry; chemical optimization; high-throughput screening

(This special issue belongs to the Section Cancer Drug Development)

Intratumoral Heterogeneity in Brain Cancers

edited by Michael Oldham

submission deadline 31 Mar 2026 | 1 articles | Viewed by 3252 | Submission Open

Keywords: intratumoral heterogeneity; brain; clonal evolution; tumor microenvironment; multiomics

(This special issue belongs to the Section Molecular Cancer Biology)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2874 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH; TERT; and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

edited by Daniel Martin

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2873 | Submission Open

Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Minimally Invasive Therapies in Urologic Cancers

edited by Eric M. Walser and

Guglielmo Manenti

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2568 | Submission Open

Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers

(This special issue belongs to the Section Methods and Technologies Development)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2268 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer

edited by Wenqing Cao

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2038 | Submission Open

Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas

(This special issue belongs to the Section Cancer Therapy)

The Role of Viruses in the Development of Cancer

edited by

George Eric Blair

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1996 | Submission Open

Keywords: DNA and RNA tumour viruses; HPV; EBV; KSHV; HCV; HBV; HTLV1; McPyV

(This special issue belongs to the Section Infectious Agents and Cancer)

Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation

edited by

Lara Edbrooke

and Chris Swain

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1708 | Submission Open

Keywords: cancer; survivorship; exercise; physical activity; implementation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research of Cancer)

The Development of Immunotherapies to Treat Lymphoma

edited by

Christina Kalpadakis

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1418 | Submission Open

Keywords: lymphoma immunotherapy; CAR T-cell therapy; immune checkpoint inhibitors; monoclonal antibodies; personalized immunotherapy

Genetic Alterations and the Tumor Microenvironment

edited by Shanye Yin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1335 | Submission Open

Keywords: tumor microenvironment; cancer immunology; immune checkpoint blockade; somatic mutations; T cell signaling; immune evasion; macrophage polarization; cancer immunotherapy resistance; single-cell transcriptomics; spatial analysis

(This special issue belongs to the Section Tumor Microenvironment)

Novel Strategies to Fight Metastatic Breast Cancer

edited by

Fernando Schmitt

and

Nuno Vale

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: breast cancer; metastasis; targeted therapy; biomarkers; personalized medicine; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Deep Learning and Radiomics for Cancer Diagnosis, Staging, and Treatment Response

edited by Mohamed Shehata,

Mostafa Elhosseini

Mahmoud Badawy

and Hanaa ZainEldin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1042 | Submission Open

Keywords: radiomics; deep learning; cancer imaging; diagnosis; staging; treatment response; machine learning; medical image analysis; precision oncology; federated learning; AI in healthcare

(This special issue belongs to the Section Methods and Technologies Development)

Diagnosis and Therapy in Urothelial Cancer

edited by

Giuseppe Palermo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 743 | Submission Open

Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management and Prognosis of Brain Metastases

edited by

Guixiang Liao

and

Muhammad Khan

submission deadline 31 Mar 2026 | Viewed by 488 | Submission Open

Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life

(This special issue belongs to the Section Cancer Therapy)

Advances on Imaging and Treatment of Head and Neck Cancer

edited by Yading Yuan, Vishruta A. Dumane,

Haibo Lin

and Luqman Dad

submission deadline 31 Mar 2026 | Viewed by 455 | Submission Open

Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning

(This special issue belongs to the Section Cancer Therapy)

Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms

edited by

Takahiro Nakajima

and George A. Eapen

submission deadline 31 Mar 2026 | Viewed by 441 | Submission Open

Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing

(This special issue belongs to the Section Cancer Therapy)

State of the Art and Advances in Kaposi Sarcoma

edited by

Athanasia Tourlaki

submission deadline 31 Mar 2026 | Viewed by 359 | Submission Open

Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Glioblastoma Stem Cells: Molecule Pathways and Cancer Therapy

edited by Shilpi Singh

submission deadline 31 Mar 2026 | Viewed by 353 | Submission Open

Keywords: glioblastoma; glioma stem cells; therapeutic resistance; tumor recurrence; tumor microenvironment; cellular and molecular pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Biomarkers of Urological Cancers

edited by

Aristotelis Bamias

Michalis Liontos

and Zisis Kratiras

submission deadline 31 Mar 2026 | 1 articles | Viewed by 274 | Submission Open

Keywords: biomarkers; urothelial cancer; prostate cancer; renal cancer; checkpoint inhibitors; PD-L1; KIM-1; FGFR3; BRCA; HRD

(This special issue belongs to the Section Cancer Biomarkers)

TGF-β Signaling in the Tumor Microenvironment: Dual Roles in Cancer Progression and Therapy

edited by

Byung-Gyu Kim

submission deadline 31 Mar 2026 | Viewed by 270 | Submission Open

Keywords: TGF-β signaling; tumor microenvironment; solid tumors; hematologic malignancies; immune modulation; therapeutic resistance; TGF-β pathway inhibitors; cancer immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition)

edited by

Mark Jesus M. Magbanua

and

Wen Li

submission deadline 31 Mar 2026 | Viewed by 255 | Submission Open

Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA

(This special issue belongs to the Section Methods and Technologies Development)

miRNAs in Targeted Cancer Therapy

edited by Mustafa Özen

submission deadline 31 Mar 2026 | Viewed by 251 | Submission Open

Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy

(This special issue belongs to the Section Cancer Therapy)

Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes

edited by

Oreste de Divitiis

and

Massimiliano Visocchi

submission deadline 31 Mar 2026 | Viewed by 247 | Submission Open

Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase

(This special issue belongs to the Section Methods and Technologies Development)

Immune Landscape of Multiple Myeloma

edited by Muhamed Baljevic and

Shebli Atrash

submission deadline 31 Mar 2026 | Viewed by 231 | Submission Open

Keywords: myeloma; immune; T cells; therapy; fitness

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Proteomics in Skin Cancer: Recent Advances

edited by

Ali Azimi

and Beatrice Dyring-Andersen

submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open

Keywords: proteomics; skin cancer; mass spectrometry; melanoma; non-melanoma skin cancers; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Flow Cytometry and Beyond: Innovative Cytometric Approaches in Cancer Detection, Profiling, and Therapeutic Monitoring

edited by

George Vartholomatos

Georgios Markopoulos

, Lefkothea Dova and Savvas Dimitriadis

submission deadline 31 Mar 2026 | Viewed by 226 | Submission Open

Keywords: cancer diagnostics; next-generation flow cytometry; AI-driven cytometry; high-dimensional single-cell analysis; cancer immunophenotyping; cytometry-based biomarkers; tumor heterogeneity; extracellular vesicles; spectral and mass cytometry; intraoperative flow cytometry

(This special issue belongs to the Section Methods and Technologies Development)

Mitochondrial Metabolism in Cancer Immune Responses

edited by

Jae Ho Seo

and Kiwon Lee

submission deadline 31 Mar 2026 | Viewed by 208 | Submission Open

Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)

edited by

Ioannis Mitroulis

, Konstantinos Liapis and

Eleni Gavriilaki

submission deadline 31 Mar 2026 | Viewed by 195 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; bone marrow micro-environment; targeted therapies; hematopoietic stem cell; leukemic stem cell; hematopoietic stem cell transplantation

(This special issue belongs to the Section Cancer Therapy)

Advances in Quantitative Imaging, AI, and Novel Imaging Techniques for Precision Radiology in Prostate Cancer

edited by Rulon R. Mayer,

Charles Simone

and

Yuan Yuan

submission deadline 31 Mar 2026 | Viewed by 186 | Submission Open

Keywords: prostate cancer; multi-parametric MRI (mpMRI); bi-parametric MRI; positron emission tomography (PET); computed tomography (CT); ultrasound (US); artificial intelligence (AI); convolutional neural network; visual language model; computer-aided diagnosis; spatially registered multi-parametric MRI; prostate specific membrane antigen in PET/CT

(This special issue belongs to the Section Methods and Technologies Development)

Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer

edited by

Marta Lukaszewicz-Zajac

and

Adrianna Romanowicz

submission deadline 31 Mar 2026 | Viewed by 172 | Submission Open

Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Screening and Surveillance of Gastrointestinal and Pancreatic Cancers

edited by Darina Kohoutová and

Jan Bures

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Real-World Clinical Studies in Acute Leukemia

edited by

Anna Candoni

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoid leukemia (ALL); refractory/relapsed leukemia; target therapy; FLT3 inhibitors; IDH (1-2) inhibitors; venetoclax; hypomethylating agents; stem cell transplantation (SCT); minimal residual disease (MRD); MRD-driven therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Lipids and Small Metabolites in Cancer—2nd Edition

edited by

Zsolt Balogi

and

Laszlo Vigh

submission deadline 31 Mar 2026 | Viewed by 145 | Submission Open

Keywords: lipid; small metabolites; cancer; metabolome- and lipidome-related mechanisms; amino acids; fatty acids; numerous components of biochemical pathways

(This special issue belongs to the Section Molecular Cancer Biology)

World Lung Cancer Awareness Month: 2nd Edition

edited by

Calvin Sze Hang Ng

submission deadline 31 Mar 2026 | Viewed by 141 | Submission Open

Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics

(This special issue belongs to the Section Cancer Therapy)

Clinical Research in Ocular Oncology

edited by Anthony Daniels,

Arun D. Singh

and

Jens Folke Kiilgaard

submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open

Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma

(This special issue belongs to the Section Clinical Research of Cancer)

Modern Approaches in Gastrointestinal (GI) Oncology: From Bench to Bedside

edited by

Francesco Fiorica

submission deadline 31 Mar 2026 | Viewed by 132 | Submission Open

Keywords: gastrointestinal oncology; radiotherapy and immunotherapy; translational cancer research; radiogenomics and AI; biomarkers and personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 351-400 on page 8 of 25.

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