State of the Art and Advances in Kaposi Sarcoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 23 September 2025 | Viewed by 154
Special Issue Editor
2. Dermatology Unit—Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan, Italy
Interests: Kaposi sarcoma; HHV8-associated malignancies; dermoscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Kaposi Sarcoma (KS) is a rare malignancy originating from endothelial cells, characterized by angiomatous lesions that appear on the skin, mucous membranes, and internal organs. It is most commonly associated with immunosuppression, particularly in HIV+ individuals, organ transplant recipients, or patients undergoing immunosuppressive treatments for other medical conditions. The disease is caused by human herpesvirus-8 (HHV-8), also known as Kaposi Sarcoma-associated herpesvirus (KSHV).
The diagnosis of KS relies primarily on histological examination, and techniques such as immunohistochemistry for HHV-8 latent nuclear antigen (LNA-1) and in situ hybridization are refining diagnostic accuracy, especially in challenging cases. Additionally, imaging methods and biomarker studies, including assessments of KSHV viral load, are being explored to enhance staging and disease monitoring.
In terms of therapy, there are different traditional approaches like chemotherapy, radiotherapy, and reduction in immunosuppressive treatment. The integration of optimized antiretroviral therapy (ART) remains pivotal in controlling HIV-associated KS and preventing disease progression. On the other hand, novel approaches are being developed to complement traditional treatments. Immunotherapy, particularly immune checkpoint inhibitors, has shown promising early results in clinical trials. Targeted therapies, such as angiogenesis inhibitors and agents that disrupt KSHV replication, are also emerging as potential options. These innovative approaches complement existing strategies and are tailored to specific aspects of KS pathophysiology.
This Special Issue will focus on the state of the art and the latest research results in the fields of pathogenesis, diagnosis, and therapy of Kaposi Sarcoma. Original research or review articles are welcome to further enrich our collective understanding and advance patient care.
Dr. Athanasia Tourlaki
Guest Editor
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Keywords
- Kaposi sarcoma
- human herpes virus 8 (HHV-8)
- oncogenesis
- chemotherapy
- targeted therapy
- immunotherapy
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