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Cancers
Special Issues
Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer
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Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 345

Special Issue Editor

Dr. Daniel Martin

E-Mail Website
Guest Editor
1. Department of Radiotherapy and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
2. German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Frankfurt, Germany
3. Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt, Germany
Interests: gastrointestinal cancers; chemoradiotherapy; radiotherapy

Special Issue Information

Dear Colleagues,

We are pleased to invite you to a Special Issue of Cancers covering neoadjuvant chemoradiotherapy (CRT) for gastrointestinal (GI) cancer, focusing on rectal cancer, esophageal cancer, gastric cancer, and pancreatic cancer. Neoadjuvant CRT has been a cornerstone in the treatment of many GI cancers, aiming for downstaging in order to improve surgical outcome and enhance survival. As a prime example, CRT has been a mainstay in rectal cancer in order to reduce local recurrences after surgery and also adds the possibility of organ preservation using a watch and wait approach after reaching a complete clinical response after neoadjuvant treatment. Pancreatic cancer, a challenging entity due to its aggressive nature, offers the possibility to include CRT in a multimodal treatment approach, especially in borderline resectable cases.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but
not limited to) the following: clinical trials, novel combinations of systemic therapies, immunotherapy, and radiotherapy, novel strategies for applying radiotherapy in order to minimize toxicities and/or improve treatment results, as well as the role of molecular markers in refining treatment strategies.

I look forward to receiving your contributions.

Dr. Daniel Martin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal cancers
  • neoadjuvant chemoradiotherapy
  • rectal cancer
  • esophageal cancer
  • pancreatic cancer
  • gastric cancer
  • immunotherapy
  • precision medicine
  • image guided radiotherapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

16 pages, 546 KB  
Article
Real-World Outcomes Between Perioperative Chemotherapy (FLOT) and Preoperative Concurrent Chemoradiotherapy (CROSS) in Localized Esophageal and Esophagogastric Junction Adenocarcinoma: A Retrospective Cohort Study
by Jirapat Wonglhow, Hui-Li Wong, Cuong Duong, John Spillane, David S. Liu, Trevor Leong, Julie Chu and Michael Michael
Cancers 2025, 17(18), 2962; https://doi.org/10.3390/cancers17182962 - 10 Sep 2025
Abstract
Background: The management of localized esophageal and esophagogastric junction (EGJ) adenocarcinomas remains challenging. Although perioperative chemotherapy with the fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen or preoperative concurrent chemoradiotherapy with carboplatin and paclitaxel (CROSS) regimen followed by surgery are standard options, the optimal [...] Read more.
Background: The management of localized esophageal and esophagogastric junction (EGJ) adenocarcinomas remains challenging. Although perioperative chemotherapy with the fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen or preoperative concurrent chemoradiotherapy with carboplatin and paclitaxel (CROSS) regimen followed by surgery are standard options, the optimal approach is still debated. This study evaluated real-world outcomes of perioperative FLOT versus preoperative CROSS in such patients. Methods: A retrospective cohort study was conducted at a tertiary cancer center in Australia, including patients treated with FLOT or CROSS between 2014 and 2024. Multivariate Cox regression models adjusted for baseline differences, including demographics, tumor stage, differentiation, location, and surgical resection. Results: Among 70 patients, 15 received FLOT and 55 received CROSS. Median overall survival (OS) was 30.3 months for FLOT and 37.5 months for CROSS (p = 0.75). Median event-free survival (EFS) was not reached in the FLOT group and was 14.8 months in the CROSS group (p = 0.49). After multivariate adjustment, differences in OS and EFS were not significant. Compared to FLOT, CROSS was associated with higher treatment completion and response rates. CROSS also led to greater pathological tumor and nodal downstaging, as well as higher rates of complete pathological response. Conclusions: Both FLOT and CROSS appear to be effective treatment options for localized esophageal and EGJ adenocarcinomas. CROSS may offer advantages in terms of treatment tolerability and tumor response, and may be particularly suitable for patients with bulky tumors or reduced performance status. Owing to the limited sample size and follow-up, these findings should be interpreted cautiously. Personalized treatment decisions should be guided by multidisciplinary discussions, considering tumor characteristics, patient condition, and access to adjuvant immunotherapy. Full article
(This article belongs to the Special Issue Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer)
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