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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 212 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 178 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 30 Apr 2026 | Viewed by 178 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 174 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 161 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 161 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 30 Apr 2026 | Viewed by 143 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life
edited by , and Juan Carlos Hernández-Rodríguez
submission deadline 30 Apr 2026 | Viewed by 133 | Submission Open
Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 129 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open
Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up
(This special issue belongs to the Section Cancer Therapy)
Management of Orbital Tumors
edited by
submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open
Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques
(This special issue belongs to the Section Clinical Research of Cancer)
Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours
edited by Crispin T. Hiley and Iain Phillips
submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR
(This special issue belongs to the Section Cancer Therapy)
EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open
Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 30 Apr 2026 | Viewed by 110 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsies in Gynecologic Cancer
edited by , and Ludovica Pepe
submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open
Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Apr 2026 | Viewed by 98 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research of Cancer)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Apr 2026 | Viewed by 98 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition)
edited by
submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open
Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Model for the Development of Anti-Cancer Drugs
edited by
submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: tumor models; preclinical cancer models; organoids and spheroids; patient-derived xenografts (PDX); syngeneic models; 3D bioprinting (tumors); tumor-on-chip; drug development; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 88 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
Adverse Effects During Cancer Treatment
edited by Yan Gong
submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open
Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment and Postoperative Outcomes of Gynecological Cancers
edited by Lauren S. Prescott
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
New Insights in Esophageal Cancer Diagnosis and Treatment
edited by
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: esophageal cancer; diagnosis; targeted screening; endoscopic treatment
(This special issue belongs to the Section Cancer Therapy)
Cutaneous T-Cell Lymphomas in Special Populations
edited by and Caroline Myers
submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open
Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research
Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology
edited by Hiroyuki Kato
submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 9667 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation
edited by
submission deadline 1 May 2026 | 3 articles | Viewed by 6082 | Submission Open
Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Medical Imaging for Cancer Detection and Diagnosis
edited by Claudia R. Mello-Thoms and Mark Anastasio
submission deadline 1 May 2026 | 1 articles | Viewed by 5437 | Submission Open
Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cell Adhesion in Human Cancer
edited by , Makoto Osanai and
submission deadline 1 May 2026 | 2 articles | Viewed by 4919 | Submission Open
Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells
(This special issue belongs to the Section Molecular Cancer Biology)
Research Advances and Therapeutic Strategies (RATS) in Cardio-Oncology submission deadline 1 May 2026 | 2 articles | Viewed by 3736 | Submission Open
Keywords: cardiotoxicity; artificial intelligence; multi-omics; cardiac toxicities; surveillance; cardioprotective agents; multimodal imaging
(This special issue belongs to the Section Cancer Therapy)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 May 2026 | 1 articles | Viewed by 3029 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth
edited by
submission deadline 1 May 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction
(This special issue belongs to the Section Cancer Biomarkers)
Advances of Particle Therapy in Prostate Cancer—2nd Edition
edited by
submission deadline 7 May 2026 | Viewed by 310 | Submission Open
Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT
(This special issue belongs to the Section Cancer Therapy)
Rehabilitation Opportunities in Cancer Survivorship
edited by and Alejandro Heredia-Ciuro
submission deadline 8 May 2026 | 3 articles | Viewed by 6637 | Submission Open
Keywords: cancer; rehabilitation; sequelae; disability; impairment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Artificial Intelligence for Cancer Precision Medicine
edited by Chenyang Shen and
submission deadline 8 May 2026 | Viewed by 68 | Submission Open
Keywords: artificial intelligence; cancer; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Epigenetics in Cancer and Drug Therapeutics
edited by Bethsebie Sailo and Anup R. Sharma
submission deadline 10 May 2026 | 1 articles | Viewed by 2499 | Submission Open
Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Hepatocellular Carcinoma Progression and Metastasis
edited by
submission deadline 10 May 2026 | 1 articles | Viewed by 2161 | Submission Open
Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial– mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy
(This special issue belongs to the Section Cancer Metastasis)
Artificial Intelligence for Network-Based Oncomarker Discovery and Cancer Prediction
edited by Oleg Blyuss
submission deadline 10 May 2026 | 3 articles | Viewed by 1929 | Submission Open
Keywords: artificial intelligence (AI); network-based biomarkers; graph neural networks (GNNs); multi-omic integration; cancer prediction; oncomarker discovery; prognostic and predictive biomarkers
(This special issue belongs to the Section Cancer Informatics and Big Data)
Genetics in Hematological Malignancies
edited by
submission deadline 10 May 2026 | 1 articles | Viewed by 1678 | Submission Open
Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling
(This special issue belongs to the Section Molecular Cancer Biology)
Targeted Therapy of Pediatric Cancer (2nd Edition) submission deadline 10 May 2026 | 1 articles | Viewed by 1234 | Submission Open
Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies
(This special issue belongs to the Section Pediatric Oncology)
Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy submission deadline 11 May 2026 | Viewed by 213 | Submission Open
Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular and Clinical Challenges in Metastatic and Oligometastatic Genitourinary Cancers
edited by Marlon Perera
submission deadline 11 May 2026 | Viewed by 41 | Submission Open
Keywords: genitourinary cancers; oligometastatic disease; metastasis-directed therapy; precision oncology; molecular profiling; biomarkers; liquid biopsy; tumour microenvironment; imaging and radiomics
(This special issue belongs to the Section Cancer Metastasis)
Systemic Treatment for Breast Cancer submission deadline 12 May 2026 | Viewed by 39 | Submission Open
Keywords: breast cancer; biomarker; treatment; management
(This special issue belongs to the Section Cancer Therapy)
Immune-Related Adverse Events in Cancer Immunotherapy
edited by Kate Young and Anna Olsson-Brown
submission deadline 15 May 2026 | 6 articles | Viewed by 15738 | Submission Open
Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Infectious Agents and Cancer in Children and Adolescents
edited by and Eleni Tsotridou
submission deadline 15 May 2026 | 4 articles | Viewed by 11390 | Submission Open
Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses
(This special issue belongs to the Section Infectious Agents and Cancer)
Endoscopic Advances in Gastrointestinal Oncology
edited by Eduardo Rodrigues-Pinto
submission deadline 15 May 2026 | 1 articles | Viewed by 5602 | Submission Open
Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging
(This special issue belongs to the Section Cancer Therapy)
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