Immune-Related Adverse Events in Cancer Immunotherapy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2176

Special Issue Editors


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Guest Editor
The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital, London, UK
Interests: medical oncology; immune checkpoint inhibitor toxicities; immunotherapy

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Guest Editor
Immunotherapy Team, The Clatterbridge Cancer Centre, Liverpool, UK
Interests: medical oncology; immune checkpoint inhibitor toxicities; immunotherapy

Special Issue Information

Dear Colleagues,

Over the last decade, immunotherapy treatments, particularly immune checkpoint inhibitors, have brought about a paradigm shift in the treatment of multiple solid tumors. These drugs are now used in many settings, from neoadjuvant through to advanced disease, across a wide variety of tumor types and in combination with other systemic anti-cancer therapies, including chemotherapy and tyrosine kinase inhibitors. While these checkpoint inhibitor drugs have revolutionized outcomes for some patients, understanding and treating their attendant side effects, or immune-related adverse events (irAEs), have provided new challenges for the oncology community. While we now know more about the spectrum of irAEs expected with ICIs, less is known about their long-term impact, how best to predict who may suffer from irAEs, how best to capture data on irAEs in clinical trials and in the real world, the mechanisms underlying the different irAEs, how best to treat them, particularly in steroid refractory cases or rarer irAEs, and how to educate our patients and the wider medical community about these very different side effects. Less is still known about the adverse events associated with some of the newer immunotherapies or combination treatments.

This Special Issue ‘Immune-Related Adverse Events in Cancer Immunotherapy’ aims to focus on these topics and more. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Kate Young
Dr. Anna Olsson-Brown
Guest Editors

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Keywords

  • check point inhibitors (CPIs)
  • immunotherapy
  • irAEs
  • immune checkpoint inhibitors (ICIs)
  • survivorship
  • long-term toxicity
  • steroid refractory
  • biologics
  • CAR-T
  • TILs

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Published Papers (1 paper)

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Review

27 pages, 1142 KiB  
Review
Hepatotoxicity in Cancer Immunotherapy: Diagnosis, Management, and Future Perspectives
by Alberto Savino, Alberto Rossi, Stefano Fagiuoli, Pietro Invernizzi, Alessio Gerussi and Mauro Viganò
Cancers 2025, 17(1), 76; https://doi.org/10.3390/cancers17010076 - 29 Dec 2024
Viewed by 1927
Abstract
Cancer immunotherapy, particularly immune checkpoint inhibitors, has positively impacted oncological treatments. Despite its effectiveness, immunotherapy is associated with immune-related adverse events (irAEs) that can affect any organ, including the liver. Hepatotoxicity primarily manifests as immune-related hepatitis and, less frequently, cholangitis. Several risk factors, [...] Read more.
Cancer immunotherapy, particularly immune checkpoint inhibitors, has positively impacted oncological treatments. Despite its effectiveness, immunotherapy is associated with immune-related adverse events (irAEs) that can affect any organ, including the liver. Hepatotoxicity primarily manifests as immune-related hepatitis and, less frequently, cholangitis. Several risk factors, such as pre-existing autoimmune and liver diseases, the type of immunotherapy, and combination regimens, play a role in immune-related hepatotoxicity (irH), although reliable predictive markers or models are still lacking. The severity of irH ranges from mild to severe cases, up to, in rare instances, acute liver failure. Management strategies require regular monitoring for early diagnosis and interventions, encompassing strict monitoring for mild cases to the permanent suspension of immunotherapy for severe forms. Corticosteroids are the backbone of treatment in moderate and high-grade damage, alone or in combination with additional immunosuppressive drugs for resistant or refractory cases. Given the relatively low number of events and the lack of dedicated prospective studies, much uncertainty remains about the optimal management of irH, especially in the most severe cases. This review presents the main features of irH, focusing on injury patterns and mechanisms, and provides an overview of the management landscape, from standard care to the latest evidence. Full article
(This article belongs to the Special Issue Immune-Related Adverse Events in Cancer Immunotherapy)
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