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Surgical Treatment and Postoperative Outcomes of Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 526

Editor


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Guest Editor
Vanderbilt University Medical Center, Nashville, TN, USA
Interests: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization

Special Issue Information

Dear Colleagues,

Gynecologic cancers, including ovarian, endometrial and cervical cancers, account for approximately 100,000 new cases and over 30,000 deaths per year in the US. Surgery is a cornerstone in treatment of most gynecologic malignancies. Although expect numbers of surgical procedures for gynecologic cancers is not known, hysterectomy is the second most common surgical procedure performed in the US.   Understanding perioperative management, changes in surgical treatment and impact of postoperative outcomes is key to providing high quality care for these patients. This special issue will explore changes in surgical treatment, preoperative optimization, best practices and quality improvement initiatives for understanding and improving care for patients with gynecologic malignancies.

Dr. Lauren S. Prescott
Guest Editor

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Keywords

  • gynecologic cancers
  • quality improvement
  • surgical outcomes
  • perioperative optimization
  • surgery
  • hysterectomy
  • ovarian cancer
  • endometrial cancer
  • cervical cancer

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Published Papers (1 paper)

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Research

12 pages, 1388 KB  
Article
Laparoscopy Prior to Laparotomy in Primary Debulking Surgery for Advanced Epithelial Ovarian Cancer in the U.S.: A National Cancer Database Analysis
by Nicole Goncalves, Kelly Lamiman, Michael Silver and Ioannis Alagkiozidis
Cancers 2026, 18(14), 2195; https://doi.org/10.3390/cancers18142195 - 8 Jul 2026
Viewed by 212
Abstract
Objective: Previous studies have demonstrated that the use of laparoscopy prior to laparotomy for primary debulking surgery (PDS) in advanced ovarian cancer is linked to lower rates of suboptimal cytoreduction. However, its impact on overall survival remains uncertain. This study aimed to compare [...] Read more.
Objective: Previous studies have demonstrated that the use of laparoscopy prior to laparotomy for primary debulking surgery (PDS) in advanced ovarian cancer is linked to lower rates of suboptimal cytoreduction. However, its impact on overall survival remains uncertain. This study aimed to compare overall survival and surgical outcomes between PDS cases initiated with laparoscopy and those without. Methods: We identified patients in the National Cancer Database who underwent PDS for stage IIIC and IV epithelial ovarian cancer between 1 January 2010 and 31 December 2017. Patients were divided into two groups for analysis: cases that were initiated with laparoscopy and those that were not initiated with laparoscopy. The primary outcome was overall survival, while secondary outcomes included 90-day postoperative mortality, 30-day readmission rate, and length of hospital stay. Statistical analyses were performed using SPSS version 29.0. Results: Among 12,532 eligible patients, 529 cases (4.2%) were initiated laparoscopically. Laparoscopy utilization increased from 3.4% to 6.9% over the study period. Rates of complete gross resection were similar between groups. Postoperative outcomes, including 90-day mortality, 30-day readmission, and hospital stay, did not differ significantly. However, laparoscopy was associated with improved overall survival in patients who proceeded to PDS (60.8 vs. 51.6 months, p = 0.012). In stage-stratified analysis, a survival benefit was noted in stage IIIC (64.5 vs. 55.2 months, p = 0.026), but not in stage IV cases. Conclusions: Despite its increasing use, the overall rate of laparoscopy before PDS remains low. Laparoscopy prior to laparotomy is associated with improved overall survival in patients with stage IIIC epithelial ovarian cancer undergoing PDS. Full article
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