Systemic Treatment for Breast Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (12 May 2026) | Viewed by 823
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast cancer is a heterogeneous disease encompassing distinct biological subtypes with unique molecular drivers and clinical behaviors. The last decade has witnessed remarkable progress in the systemic management of breast cancer, with the introduction of targeted agents, immunotherapy, and antibody–drug conjugates, leading to improved survival outcomes across disease stages. However, several unmet needs remain, including optimization of treatment sequencing, management of primary and acquired resistance, and development of predictive biomarkers to enable individualized therapeutic strategies.
This Special Issue will focus on the latest advances in systemic therapy for breast cancer, spanning the spectrum from early-stage to metastatic disease. We encourage the submission of original research articles, clinical trials, translational studies, and comprehensive reviews. Topics of interest include, but are not limited to, the following:
- Endocrine therapy and CDK4/6 inhibitor optimization in HR+/HER2− disease;
- Novel strategies for HER2-positive, HER2-low, and triple-negative breast cancer;
- Real-world evidence on antibody–drug conjugates, PARP inhibitors, and immune checkpoint inhibitors;
- Biomarker-driven patient selection, early response assessment, and treatment de-escalation/escalation strategies;
- Mechanisms of treatment resistance and strategies to overcome them;
- Toxicity management, survivorship, and quality-of-life outcomes;
- Multidisciplinary and health-economics approaches to systemic treatment.
By gathering high-quality contributions, this Special Issue aims to provide clinicians and researchers with state-of-the-art knowledge to guide personalized treatment decisions and ultimately improve patient outcomes.
Dr. Luigia Stefania Stucci
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- biomarker
- treatment
- management
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
