Liquid Biopsies in Gynecologic Cancer

Dear Colleagues,

Gynecologic cancers represent a significant cause of morbidity and mortality for women worldwide. Their management is often complicated by nonspecific early symptoms, leading to diagnosis at an advanced stage. Traditional approaches to diagnosis and disease monitoring rely on invasive tissue biopsies and imaging techniques, which have inherent limitations for real-time assessment of tumor evolution and treatment response. Recently, there has been significant progress in the field of liquid biopsies. This minimally invasive approach has the potential to revolutionize the clinical management of these tumors. The analysis of circulating biomarkers, such as circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes, has been shown to offer crucial insights for early detection, monitoring for minimal residual disease, and guiding personalized therapies. These advances in technology and molecular research have helped improve the prognosis of patients with advanced disease.

This Special Issue aims to expand our knowledge on the recent advances in the diagnosis, treatment, and prognosis of gynecologic cancers using liquid biopsy. Original research articles, reviews, case series, letters and commentary are welcome.

We look forward to receiving your contributions.

Dr. Antonio Ieni
Dr. Vincenzo Fiorentino
Dr. Ludovica Pepe
Guest Editors

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