cancers-logo

Journal Browser

Journal Browser

Research and Clinical Applications of Gynecologic Cancer Detection Technologies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 759

Editor


E-Mail Website
Guest Editor
Northern Gynecological Oncology Centre, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK
Interests: cervical cancer; radical hysterectomy; robotic surgery

Special Issue Information

Dear Colleagues,

Gynaecological cancers remain a significant global health challenge. The increased understanding of the genetic and molecular aspects of these tumours is helping us develop effective screening programmes, but still, around 1.5 million women diagnosed with gynaecological cancer during 2022. These statistics highlight the need for improved prevention and early detection to obtain the best outcomes for our patients.

This Special Issue of Cancers therefore will be focused on new diagnostic approaches for early detection of Gynaecological Cancers. It will also explore how new technologies will enhance our ability to diagnose these cancers earlier and to increase the sensitivity and specificity of the existing screening methods.

Dr. Porfyrios Korompelis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynaecological cancer
  • early diagnosis
  • artificial intelligence
  • novel technologies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 554 KB  
Article
Hybrid 99mTc–ICG Sentinel Lymph Node Mapping in Apparent Early-Stage Epithelial Ovarian Cancer: A First Prospective Evaluation of a True Molecular Hybrid Tracer (HibrOv Trial)
by Joana Amengual Vila, Catalina Maria Sampol Bas, Adriana Quintero Duarte, Ane Ugarteburu Pérez, Mario Ruiz Coll, Jorge Rioja Merlo and Anna Torrent Colomer
Cancers 2026, 18(12), 1973; https://doi.org/10.3390/cancers18121973 - 17 Jun 2026
Viewed by 408
Abstract
Background/Objectives: Systematic lymphadenectomy is recommended in apparent early-stage epithelial ovarian cancer (EOC) to assess nodal status, but it is associated with significant morbidity and lacks survival benefit. Sentinel lymph node (SLN) mapping may offer a less invasive alternative, although evidence remains limited [...] Read more.
Background/Objectives: Systematic lymphadenectomy is recommended in apparent early-stage epithelial ovarian cancer (EOC) to assess nodal status, but it is associated with significant morbidity and lacks survival benefit. Sentinel lymph node (SLN) mapping may offer a less invasive alternative, although evidence remains limited due to the complexity of ovarian lymphatic drainage and methodological heterogeneity across studies. This prospective study evaluates the feasibility and diagnostic accuracy of a true hybrid 99mTc–indocyanine green (ICG) tracer for SLN mapping in apparent early-stage EOC. Methods: A prospective observational study was conducted at a tertiary oncology center between 2021 and 2026. Patients presenting with a suspicious ovarian mass (Group A) or requiring restaging after adnexectomy for confirmed EOC (Group B) underwent SLN mapping using a hybrid 99mTc–ICG tracer injected into the infundibulopelvic (IPL) and/or utero-ovarian ligament (UOL). SLNs were identified using gamma detection and near-infrared fluorescence imaging. All malignant cases underwent complete surgical staging including systematic pelvic and para-aortic lymphadenectomy. SLNs were ultrastaged and compared with the final nodal status. Results: Forty patients were included; 20 (50%) had malignant tumors. The overall SLN detection rate was 92.5% (37/40), with 100% in malignant cases. Among malignant tumors, 3/20 (15%) had metastatic SLNs, all accurately detected (false-negative rate 0%). Sensitivity and negative predictive value were 100%. Combined pelvic and para-aortic drainage was the most frequent pattern (75%). Conclusions: SLN mapping may represent a feasible and potentially accurate staging strategy in apparent early-stage EOC. In the present study, a hybrid 99mTc–ICG tracer was associated with high detection rates and complete concordance with final nodal status. These findings support further multicenter validation to define its potential role as an alternative to systematic lymphadenectomy. Full article
Show Figures

Figure 1

Back to TopTop