Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 72
Special Issue Editors
Interests: urologic oncology; kidney cancer; translational research; testicular cancer; upper tract urothelial carcinoma
Special Issues, Collections and Topics in MDPI journals
Interests: kidney cancer; translational research; biomarkers; clinical trials; immune-oncology; testicular cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of a previous issue on the topic of “Advances in Locally Advanced and Metastatic Kidney Cancer”.
Our biological understanding and clinical management of kidney cancer has advanced significantly in recent years. In particular, the introduction of novel immune checkpoint inhibitors has led to unprecedented responses in metastatic disease and improved patient survival. These developments have paved the way for the emergence of rational, synergistic combinations of immunotherapies and targeted therapies.
Advanced renal cell carcinoma (RCC) exhibits a wide clinical spectrum, ranging from non-metastatic, high-risk or locally advanced tumors, to oligometastatic disease, to more widely disseminated metastatic involvement. In the locally advanced setting, there is increasing interest in administering systemic therapies in the perioperative (neoadjuvant or adjuvant) setting to reduce recurrence. In the study of oligometastatic disease, new approaches to the locoregional management of metastatic sites, such as stereotactic radiation, have been employed to delay or obviate the need for systemic therapy while minimizing morbidity. In more widely disseminated disease, novel therapeutic agents and rational combinations continue to emerge for both clear cell and non-clear cell RCC histologies. The role and timing for cytoreductive nephrectomy in metastatic disease continue to evolve, and the optimal setting remains uncertain. Furthermore, diagnostic, prognostic, and predictive circulating biomarkers remain an active area of research interest across the spectrum of RCC, while advances in diagnostic imaging are contributing to both improved diagnosis and potential theranostic applications.
In this Special Issue, we are seeking high-quality, original work that highlights advances in locally advanced and metastatic kidney cancer, pertaining to the themes outlined above. We look forward to receiving your contributions.
Dr. Nirmish Singla
Dr. Yasser Ged
Guest Editors
Manuscript Submission Information
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Keywords
- kidney cancer
- renal cell carcinoma
- locally advanced
- oligometastatic
- metastatic
- novel therapeutics
- diagnostic imaging
- biomarkers
- multimodal treatment
- cytoreductive nephrectomy
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