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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancers Hijack Immune Surveillance and Tumor Microenvironment Leading to Immune Evasion

edited by

Yona Keisari

, Viktor Umansky and

Rostyslav Bilyy

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2395 | Submission Open

Keywords: anti-tumor immunity; cancer immunotherapy; immune evasion; immune response modulation; immunosuppression; immune surveillance; manipulating IR components function and migration; metabolic modulation of the TME; metabolic reprogramming; tumor-associated immune cells; tumor microenvironment (TME)

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Trials and Outcomes for Non-Small Cell Lung Cancer

edited by

Ana Rodrigues

and

António Araújo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2371 | Submission Open

Keywords: non-small cell lung cancer; oncogenic alterations; clinical trial; systemic therapy; targeted therapy; immunotherapy; radiotherapy; real-world data; surgery; drug development

(This special issue belongs to the Section Clinical Research of Cancer)

Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches

edited by

Lucía Ortiz-Comino

, Avraham Eisbruch and

Ángela González-Santos

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1999 | Submission Open

Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions

(This special issue belongs to the Section Cancer Therapy)

Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1810 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

edited by

Matteo Donadon

and

Guido Torzilli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1541 | Submission Open

Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advanced Glycation End-Products and Its Receptors in Cancer Progression

edited by Bhaumik B. Patel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1462 | Submission Open

Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)

(This special issue belongs to the Section Tumor Microenvironment)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1138 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Emerging Technologies in Thoracic Surgery

edited by Filippo Lococo and

Carolina Sassorossi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Nutrition in Survivors with Advanced Cancer: The Role of Appetite, Muscle Wasting, Obesity, and Altered Body Composition

edited by Egidio Del Fabbro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1054 | Submission Open

Keywords: advanced cancer; nutrition; wasting; body composition; multimodal

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Jan 2026 | 2 articles | Viewed by 925 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | 1 articles | Viewed by 823 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)

edited by

Naoshi Nishida

submission deadline 31 Jan 2026 | 1 articles | Viewed by 633 | Submission Open

Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights in Nanomedicine and Targeted Drugs for Breast Cancer

edited by

Maria Gazouli

, Gennaro Sanità, Alessandro Venuta and Rosarita Nasso

submission deadline 31 Jan 2026 | Viewed by 454 | Submission Open

Keywords: breast cancer; nanoparticles; active targeting; BC; nanomedicine

(This special issue belongs to the Section Cancer Drug Development)

The Cancer Stem Cells and the Quiescence

edited by

Bhopal Mohapatra

submission deadline 31 Jan 2026 | Viewed by 415 | Submission Open

Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis

edited by

Vincent Balaya

Marcin Sniadecki

and Thomas Gaillard

submission deadline 31 Jan 2026 | Viewed by 362 | Submission Open

Keywords: cervical cancer; lymph nodes; metastasis; isolated Tumor Cells; sentinel lymph node; non-sentinel lymph node; tumor-draining lymph nodes; microenvironment; one-step nucleic acid amplification; imaging

(This special issue belongs to the Section Tumor Microenvironment)

Neoadjuvant Therapy for Urologic Cancer

edited by Marlon Perera and David Chen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 336 | Submission Open

Keywords: urologic oncology; neoadjuvant therapy; treatment; improved survival

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by Shuji Isaji

submission deadline 31 Jan 2026 | Viewed by 264 | Submission Open

Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2026 | Viewed by 239 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications

edited by

Whi-An Kwon

submission deadline 31 Jan 2026 | Viewed by 211 | Submission Open

Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Cancer Biology)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 31 Jan 2026 | Viewed by 205 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by

Luis Colomo

and

Francesco Lanza

submission deadline 31 Jan 2026 | Viewed by 196 | Submission Open

Keywords: hematologic malignancies; diagnosis; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Breast Cancer and Stem Cells

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2026 | Viewed by 181 | Submission Open

Keywords: breast cancer; cancer stem cells; tumor microenvironment; metastasis; therapeutic strategies; in vitro models

(This special issue belongs to the Section Molecular Cancer Biology)

Curative Therapies for Non-Small and Small Cell Lung Cancers

edited by John Michael Varlotto

submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open

Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers

edited by

Takashi Murakami

submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open

Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

edited by Francesco Mattioli,

Alfredo Lo Manto

and Edoardo Serafini

submission deadline 31 Jan 2026 | Viewed by 146 | Submission Open

Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Transformative Drug Innovations Reshaping Myeloma Treatment

edited by Despina Fotiou

submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open

Keywords: multiple myeloma; cellular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy

edited by

Paulina Mertowska

submission deadline 31 Jan 2026 | Viewed by 132 | Submission Open

Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Personalized Cancer Therapy: Strategies for Overcoming On-Target and Bypass Resistance

edited by

Valentina Foglizzo

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: resistance mechanisms; biomarker; oncogene dependency; target therapy; personalized therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Thoracic Oncology Research

edited by

Domenico Galetta

submission deadline 1 Feb 2026 | 1 articles | Viewed by 2954 | Submission Open

Keywords: lung cancer; mediastinal; thymic; neuroendocrine; robotic; VATS; chest wall; chemotherapy; immunotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Therapy for HER2 Breast Cancer

edited by

Junji Tsurutani

and Sandra M. Swain

submission deadline 1 Feb 2026 | Viewed by 160 | Submission Open

Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy in Clinical and Translational Research

edited by Sofia Genta

submission deadline 10 Feb 2026 | 8 articles | Viewed by 31235 | Submission Open

Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Insights into Prostate Cancer Radiotherapy

edited by

Grace Lu-Yao

submission deadline 10 Feb 2026 | 6 articles | Viewed by 15510 | Submission Open

Keywords: prostate cancer; radiotherapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Radiotherapy

edited by

Michael L. F. Lerch

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2734 | Submission Open

Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in the Field of Radiotherapy Treatment for Lung Cancer

edited by Ioannis C. Maroulis

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1931 | Submission Open

Keywords: lung cancer; radiotherapy; non-small-cell lung cancer (NSCLC)

(This special issue belongs to the Section Cancer Therapy)

Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

edited by

Chencheng Xie

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Surgical Treatment of Gynecological Cancers

edited by

Denis Querleu

, Joanna P. Kacperczyk-Bartnik and

Aleksandra Strojna

submission deadline 14 Feb 2026 | 2 articles | Viewed by 3098 | Submission Open

Keywords: gynecological oncology; image-guided surgery; lymphadenectomy; minimally invasive surgery; ovarian cancer surgery; patient outcomes; perioperative care; precision surgery; radical hysterectomy; robotic-assisted surgery; surgical oncology

(This special issue belongs to the Section Cancer Therapy)

Metronomic Chemotherapy in Female Cancers

edited by

Luca Roncati

submission deadline 14 Feb 2026 | 1 articles | Viewed by 1951 | Submission Open

Keywords: metronomic chemotherapy; female cancers; anti-tumor mechanisms; clinical trials and outcomes; combination therapies

(This special issue belongs to the Section Cancer Therapy)

New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer

edited by Kelsie L. Thu

submission deadline 15 Feb 2026 | 5 articles | Viewed by 18479 | Submission Open

Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

New Strategies in Diagnosis and Treatments for Brain Tumors: 2nd Edition

edited by Sven Rainer Kantelhardt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 16890 | Submission Open

Keywords: glioma; brain tumor; molecular guided therapy; personal medicine; radiomics; digital analysis; artificial intelligence; intraoperative imaging; surgical resection

(This special issue belongs to the Section Cancer Therapy)

Advances in Esophageal Cancer

edited by Sacheen Kumar

submission deadline 15 Feb 2026 | 4 articles | Viewed by 9161 | Submission Open

Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

edited by

Daniela Cornelia Lazăr

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2749 | Submission Open

Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence

edited by

Yuzuru Niibe

Dai Sonoda

and

Tadahiko Shien

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2521 | Submission Open

Keywords: oligometastases; oligo-recurrence; sync-oligometastases

(This special issue belongs to the Section Cancer Metastasis)

The Elderly Multiple Myeloma Patient in the Era of Quad Therapy and CAR-T Cells

edited by James J. Ignatz-Hoover and Koen Van Besien

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1833 | Submission Open

Keywords: multiple myeloma; quad therapy; CAR-T; elderly

(This special issue belongs to the Section Cancer Therapy)

Advances in Precision Medicine: Targeting Known and Emerging Oncogenic Targets in Lung Cancer (2nd Edition)

edited by

Tianhong Li

submission deadline 15 Feb 2026 | Viewed by 228 | Submission Open

Keywords: precision oncology; lung cancer; oncogenic target; targeted therapy; biomarker; diagnosis

(This special issue belongs to the Section Molecular Cancer Biology)

Epigenetics and Non-Coding RNAs in Multiple Myeloma

edited by

Rui Bergantim

submission deadline 15 Feb 2026 | Viewed by 153 | Submission Open

Keywords: multiple myeloma; epigenetics; non-coding RNAs; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); circular RNAs (circRNAs); DNA methylation; histone modifications; drug resistance; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Genetic Changes in CNS Neoplasms

edited by Kimberly Bojanowski Hoang

submission deadline 15 Feb 2026 | Viewed by 116 | Submission Open

Keywords: primary brain tumor; secondary brain tumor; metastasis; glioma; genetics; genomics; CNS; neoplasms

(This special issue belongs to the Section Cancer Biomarkers)

Prognostic and Predictive Biomarkers in Ovarian Cancer

edited by Jayakumar Nair

submission deadline 15 Feb 2026 | Viewed by 55 | Submission Open

Keywords: molecular biomarkers; clinical biomarkers; immune biomarkers; genetic biomarkers; ovarian cancer; personalized medicine

(This special issue belongs to the Section Cancer Biomarkers)

Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 16 Feb 2026 | 4 articles | Viewed by 9352 | Submission Open

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)

edited by

Anna Kakehashi

and Min Gi

submission deadline 18 Feb 2026 | 2 articles | Viewed by 11716 | Submission Open

Keywords: cancer; screening; diagnosis; anti-cancer; drugs; mechanisms of carcinogenesis; chemopreventive agents

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Cancers

edited by

Sudhir Rai

and

Seema Kumari

submission deadline 20 Feb 2026 | 3 articles | Viewed by 12424 | Submission Open

Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins

(This special issue belongs to the Section Tumor Microenvironment)

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