Radiosensitivity and Radiotoxicity in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 53

Special Issue Editor


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Guest Editor
DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece
Interests: radiation biology; cancer biology; DNA damage and repair; oxidative stress; carcinogenesis
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Special Issue Information

Dear Colleagues,

Radiation therapy is considered the primary modality in cancer treatment. Technological improvements have optimized radiation therapy systems toward more precise dose delivery in the tumor area while at the same time minimizing unwanted doses to normal tissues.

Two of the most critical parameters for the successful outcome for any tumor treatment are radiosensitivity of the tumor and the radiotoxicity of normal tissues, leading to a range of adverse effects in patients in the short and long terms. With this Special Issue, we aim to identify and shed light to the pathways and mechanisms leading to improved tumor treatment using different types of radiation, from X-rays, electrons, to protons and carbons. Advancements in radiation therapy systems are also of great interest. Therefore, groups working on different aspects of radiation therapy, from accelerators to clinical outcomes, combinations with immunotherapy, FLASH, or other modalities, are welcome to submit their research or review work. Preclinical and clinical trials are also welcome to be included. Although the primary emphasis will be on human patients, other non-human patient studies are also welcome to be submitted. Groups working on genetic factors and biomarkers are encouraged to consider this Special Issue. Last but not least, based on the development of important roles of bioinformatics and systems biology, studies using specific tools for the delineation of molecular pathways improving tumor control and/or reducing toxicity are invited to be submitted. 

Prof. Dr. Alexandros Georgakilas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiation therapy
  • clinical outcome
  • radiosensitivity
  • radiotoxicity
  • biomarkers
  • bioinformatics
  • systems biology

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Published Papers

This special issue is now open for submission.
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