Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 784

Special Issue Editors


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Guest Editor
Department of Public Health, Kurume University School of Medicine, Kurume, Japan
Interests: oligometastases; oligo-recurrence; sync-oligometastases; urological cancer; breast cancer; thoracic cancer; radiation oncology
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Guest Editor
Department of Thoracic Surgery, Kitasato University School Medicine, Sagamihara, Japan
Interests: thoracic surgery; oligo-recurrence
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Guest Editor
Department of Breast Surgery and Endcrinological Surgery, Okayama Univercity Hospital, Okayama, Japan
Interests: breast surgical oncology; clinical trials; translational research; oligo-recurrence
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Special Issue Information

Dear Colleagues,

The concept that has brought about the most significant change in clinical oncology in recent decades is oligometastases. Among these, the concept of oligo-recurrence, which is said to have a good prognostic subgroup among oligometastases, is the most important. Oligo-recurrence is a concept of recurrent cancer proposed by Niibe Y et al. in 2006.

Oligo-recurrence suggests that when the primary cancer tumor is controlled and 1–5 cases of recurrent or metastatic cancer occur, adding local therapy to systemic therapy may lead to long-term survival or even cure (in rare cases, only local treatment without systemic therapy).

In this Special Issue, we would like to use this as a place to discuss the basis for the fact that the concept of oligometastases is not a hypothesis and that oligo-recurrence is no longer a hypothesis.

We look forward to hearing from you.

Prof. Dr. Yuzuru Niibe
Dr. Dai Sonoda
Prof. Dr. Tadahiko Shien
Guest Editors

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Keywords

  • oligometastases
  • oligo-recurrence
  • sync-oligometastases

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Published Papers (1 paper)

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Review

19 pages, 400 KiB  
Review
Characteristics of Oligo-Recurrence and Treatment Selection in Non-Small Cell Lung Cancer
by Dai Sonoda, Yasuto Kondo, Satoru Tamagawa, Masahito Naito, Masashi Mikubo, Kazu Shiomi, Kazuhiro Yasufuku and Yukitoshi Satoh
Cancers 2025, 17(14), 2293; https://doi.org/10.3390/cancers17142293 - 10 Jul 2025
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Abstract
Recent advances in technology and pharmacologic agents have significantly improved both local and systemic therapies, making the treatment of non-small cell lung cancer (NSCLC) more effective and less invasive. However, recurrence after radical resection remains a major clinical challenge. Among the various recurrence [...] Read more.
Recent advances in technology and pharmacologic agents have significantly improved both local and systemic therapies, making the treatment of non-small cell lung cancer (NSCLC) more effective and less invasive. However, recurrence after radical resection remains a major clinical challenge. Among the various recurrence patterns, oligo-recurrence—particularly metachronous oligo-recurrence, characterized by a limited number of metastatic lesions appearing after a disease-free interval—has gained attention due to its potential for long-term survival and even cure through local therapy. Concurrently, systemic treatments have advanced with the development of molecularly targeted therapies and immune checkpoint inhibitors. Numerous studies have demonstrated their clinical efficacy, resulting in significant improvements in patient prognosis. Therefore, selecting an appropriate treatment strategy for recurrent NSCLC involves a broad spectrum of therapeutic options, including targeted therapies, immune checkpoint inhibitors, and conventional chemotherapy. Treatment decisions are particularly complex in cases of oligo-recurrence, where local therapy is feasible, making it challenging to choose the best approach from the available options. This narrative review summarizes current evidence from retrospective and ongoing prospective trials and discusses the clinical characteristics and treatment strategies for oligo-recurrent NSCLC. Full article
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