The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 536
Special Issue Editor
Interests: hepatocellular carcinoma; molecular classification; tumor microenvironment; genome; epigenome; transcriptome; diagnosis; treatment; molecular targeted agent; multikinase inhibitor; immune checkpoint inhibitor; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of “The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies”.
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with a high recurrence rate and mortality. Although the biological behavior of HCC is complex, where a variety of oncogenic pathways are involved, recent analyses of the genome, epigenome, and transcriptome indicate a sophisticated molecular classification of this type of cancer that reflects HCC biology. Such “omics” analyses allow us to show a responsible cancer pathway and help to develop specific molecular targeted agents as well as understand cancer biology in each case. In addition, it is known that omics-based classifications are also associated with the immune phenotype of HCC, which should affect the efficacy of immune-based treatment, including immune checkpoint inhibitors in addition to molecular targeted agents. From these points of view, understanding biology in each HCC is required to establish the personalized medicine expected for the effective treatment of cancer.
From this point of view, this Special Issue will highlight the current state of the art in genetic and immune therapies based on the biological understanding of HCC from both basic and clinical aspects.
In addition, recent technology in artificial intelligence (AI) is playing a critical role in applying omics data to understanding the biology in each HCC; AI-based analyses of precision medicine are also welcome.
Prof. Dr. Naoshi Nishida
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hepatocellular carcinoma
- diagnosis
- treatment
- molecular targeted agent
- immune checkpoint inhibitor
- artificial intelligence
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