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Cancers
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Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd...
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Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 596

Special Issue Editors

Prof. Dr. Matteo Donadon
*
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Guest Editor
University Maggiore Hospital, University of Piemonte Orientale, 28100 Novara, Italy
Interests: liver; laparoscopic surgery; intraoperative US of liver
* Director of Surgical Oncology Program
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Guido Torzilli

E-Mail Website
Guest Editor
Division of Hepatobiliary Surgery & General Surgery, Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: liver; laparoscopic surgery; intraoperative US of liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous one, entitled “Advanced Strategies in the Care of Hepatocellular Carcinoma Patients” (https://www.mdpi.com/journal/cancers/special_issues/C_HC).

We are honored to be the Guest Editors of this Special Issue of Cancers that summarizes current research in the diagnosis and treatment of hepatocellular carcinoma (HCC). HCC is the most common primary liver cancer, with geographical variations among its prevalence. With HCC still being the leading cause of death in patients with cirrhosis, and considering the worldwide increasing incidence in patients with underlying metabolic associated liver disease, working on HCC should be one of the research priorities. In this Special Issue, we welcome papers that enhance our knowledge of innovative diagnostic and prognostic methods and discuss the results of therapeutic experimentation, including those focused on translational research.

We look forward to receiving your contributions.

Prof. Dr. Matteo Donadon
Prof. Dr. Guido Torzilli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatocellular carcinoma
  • hepatic resection
  • hepatectomy
  • liver resection
  • liver surgery
  • parenchymal-sparing liver surgery
  • intraoperative ultrasound
  • liver-specific magnetic resonance imaging
  • trans-arterial therapy
  • liver function
  • FibroScan

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Published Papers (1 paper)

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16 pages, 1024 KiB  
Systematic Review
Efficacy of Transarterial Chemoembolization Combined with Tyrosine Kinase Inhibitors for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
by Tzu-Rong Peng, Yi-Fang Weng, Ta-Wei Wu, Chao-Chuan Wu, Chia-Lu Hsu and Ching-Sheng Hsu
Cancers 2025, 17(13), 2110; https://doi.org/10.3390/cancers17132110 - 24 Jun 2025
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Abstract
Background: Transarterial chemoembolization (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC); however, its survival benefits remain unsatisfactory. In this systematic review, we aimed to compare the clinical outcomes of tyrosine kinase inhibitors (TKIs) combined with TACE and TACE alone [...] Read more.
Background: Transarterial chemoembolization (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC); however, its survival benefits remain unsatisfactory. In this systematic review, we aimed to compare the clinical outcomes of tyrosine kinase inhibitors (TKIs) combined with TACE and TACE alone in patients with intermediate-stage HCC. Methods: A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Randomized controlled trials (RCTs) comparing TACE plus TKIs with TACE alone in patients with HCC were retrieved from PubMed, Embase, and the Cochrane Library. The primary outcomes included overall survival (OS) and progression-free survival (PFS), reported as hazard ratios (HRs) with 95% confidence intervals (CIs). Secondary outcomes included the overall response rate (ORR) and disease control rate (DCR), which were analyzed using risk ratios (RRs). Heterogeneity was assessed using the I2 statistic. Results: Fourteen RCTs were included in this meta-analysis. Compared to TACE alone, TACE plus TKIs significantly improved PFS (HR = 0.74, 95% CI: 0.59–0.93, p = 0.01, I2 = 87%) and the ORR (RR = 1.29, 95% CI: 1.11–1.51, p = 0.001), but not OS (HR = 0.84, 95% CI: 0.69–1.03, p = 0.10, I2 = 65%) and the DCR (RR = 1.05, 95% CI: 0.99–1.11, p = 0.08). Subgroup analysis showed that TACE plus TKIs significantly increased OS in patients with hepatitis B virus (HBV) infection (HR = 0.67, 95% CI: 0.51–0.88), but not in those with hepatitis C virus (HCV) infection or those without HBV and HCV infection. Moreover, patients with HBV infection, male patients, and those with a good functional status (ECOG performance status of 0) had better PFS than others. Conclusions: Compared with TACE alone, TACE combined with TKIs can significantly improve PFS and the ORR in patients with intermediate-stage HCC. Furthermore, combination treatment can significantly improve OS in patients with HBV infection, but not in patients with HCV infection. Further research is required to optimize patient selection and treatment strategies. Full article
(This article belongs to the Special Issue Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition))
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