Advanced Glycation End-Products and Its Receptors in Cancer Progression

Dear Colleagues,

Advanced glycation end products (AGEs) are a group of compounds formed when sugars react with proteins and lipids in the body. They have been implicated in various diseases, including cancer, through receptors for AGE (RAGEs), as well as dependent and independent mechanisms. An increasing body of literature implicates AGEs/RAGEs in various hallmarks of cancer, including the tumor immune microenvironment (TME), inflammation and cancer stem cells (CSCs). 

In this Special Issue, we aim to explore the latest research findings and advancements in understanding the role of AGEs in cancer. The issue will focus on the biochemistry and clinical detection of AGEs, their clinical relevance and biology, and the molecular mechanism of AGE/RAGE-induced carcinogenesis or therapeutic strategies targeting AGEs/RAGEs in cancer. We especially invite articles examining the role of glycosaminoglycans (GAGs) in regulating AGEs/RAGEs in cancer, as well as CSC biology and the role of AGEs/RAGEs in inflammatory TME and therapeutic targeting thereof. 

Dr. Bhaumik B. Patel
Guest Editor

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