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Neoadjuvant Therapy for Urologic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1866

Special Issue Editors


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Guest Editor
1. Department of Urology, The Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC 3052, Australia
2. Department of Surgery, University of Melbourne, Melbourne, VIC 3052, Australia
3. Department of Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia
4. Department of Urology, Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia
Interests: prostate cancer; urologic oncology; registry-based research; radical prostatectomy; clinical trials

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Guest Editor Assistant
Department of Urology, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia
Interests: cancer

Special Issue Information

Dear Colleagues,

Neoadjuvant therapy plays a crucial role in optimizing surgical outcomes and improving survival in urologic malignancies. By integrating historical insights, biological mechanisms, and future directions, this Special Issue will explore the evolving landscape of neoadjuvant strategies in urologic oncology.

We invite original research articles and reviews that address key developments in this field, including novel therapeutic approaches, biomarkers for response prediction, and clinical trial outcomes. Topics may also include mechanistic insights and translational advances.

We look forward to your contributions to this important discussion on the future of neoadjuvant therapy in urologic oncology.

Dr. Marlon Perera
Guest Editor

Dr. David Chen
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • urologic oncology
  • neoadjuvant therapy
  • treatment
  • improved survival

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Published Papers (1 paper)

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Review

16 pages, 445 KB  
Review
Neoadjuvant Therapies for Prostate Cancer–Current Paradigms and Future Directions
by Kieran Sandhu, Abdullah Al-Khanaty, David Hennes, David Chen, Eoin Dinneen, Carlos Delgado, Nathan Lawrentschuk, Renu S. Eapen, Declan G. Murphy and Marlon Perera
Cancers 2026, 18(1), 65; https://doi.org/10.3390/cancers18010065 - 24 Dec 2025
Viewed by 1520
Abstract
High-risk and locally advanced prostate cancer represents 20–25% of new diagnoses of prostate cancer and is associated with high rates of recurrence, morbidity, and mortality. The neoadjuvant window provides a unique opportunity for systemic control prior to definitive therapy with radical prostatectomy or [...] Read more.
High-risk and locally advanced prostate cancer represents 20–25% of new diagnoses of prostate cancer and is associated with high rates of recurrence, morbidity, and mortality. The neoadjuvant window provides a unique opportunity for systemic control prior to definitive therapy with radical prostatectomy or radiotherapy (RT). Early trials with first-generation androgen deprivation therapy (ADT) achieved pathological downstaging but no survival benefit. In the 2000s, the advent of chemohormonal regimes using docetaxel provided excitement but mixed results tempered expectations and is now not recommended prior to surgery. Second-generation androgen receptor pathway inhibitors (ARPIs) combined with ADT have demonstrated significant survival benefit in metastatic prostate cancer and are currently being evaluated in large phase III trials in the neoadjuvant setting. RT remains an alternative curative modality, and recent data highlights similar issues to surgery in eradicating micrometastatic disease despite excellent local control. This has driven parallel efforts to evaluate intensified systemic therapy in the pre-RT/neoadjuvant settings. In addition to the excitement surrounding ARPIs, radioligand therapy, such as [177Lu]Lu-PSMA-617 has shown promise in the neoadjuvant setting and continues to be investigated. Future research aims to incorporate genomic and molecular factors to enable personalised neoadjuvant therapies by identifying damage immunologically responsive subtypes that may derive greater benefit from immune-directed therapies in the peri-operative setting. This narrative review synthesises current evidence for neoadjuvant therapies in high-risk prostate cancer and future directions. Full article
(This article belongs to the Special Issue Neoadjuvant Therapy for Urologic Cancer)
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