Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 2670
Special Issue Editor
2. Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Interests: breast cancer; pancreatic cancer; non-small-cell lung cancer; neuroinflammation; NLRP3; microRNA; inflammasome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) is defined as a complex ecosystem of cellular and non-cellular components where cancer grows. Cellular components include not only cancer cells but also many other types of cells, including cancer-associated stromal and infiltrating immune cells that play critical roles in cancer biology. The non-cellular components comprise signaling molecules and proteins of the extracellular matrix (ECM). Cancer cells influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing immune tolerance where the stromal and immune cells help cancer cells to escape immune recognition, providing a pro-tumorigenic environment to develop drug resistance in order to metastasize and exhibit even more malignant behaviors. By targeting the TME, it is possible to disrupt the interactions between tumor cells and other cells in the microenvironment, preventing tumor growth and metastasis. We invite authors to contribute cutting-edge studies to this Special Issue, entitled “Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy”, to further highlight the challenges and opportunities associated with TME-targeted therapy.
In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following:
- VEGF/VEGFR-targeted therapy;
- Immune checkpoint blockade;
- Recent advances and challenges in tumor microenvironment targeting;
- Targeting cancer stem cells;
- Tumor microenvironment and its therapeutic implications.
- Microbiome
We look forward to receiving your contributions.
Dr. Inamul Haque
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- VEGF/VEGFR-targeted therapy
- immune checkpoint blockade
- recent advances and challenges in tumor microenvironment targeting
- targeting cancer stem cells
- tumor microenvironment and its therapeutic implications
- microbiome
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