Multifunctional Enzymes and Proteins: New Insights into Structure and Function
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 2188
Special Issue Editors
Interests: enzymatic activity; tumor enzymes; protein characterization; biochemistry; biomolecular interactions; molecular biology
Special Issues, Collections and Topics in MDPI journals
Interests: biochemistry; microalgae; biotechnology; antioxidants
Special Issues, Collections and Topics in MDPI journals
Interests: protein function; protein–protein interaction; molecular mechanism; peptide synthesis; cell cycle; cell biology; cancer
Special Issue Information
Dear Colleagues,
Multifunctional enzymes and proteins represent a crucial class of biomolecules whose actions extend beyond a single role. Increasing attention has been directed toward these molecules that perform diverse roles in cellular regulation, signaling, metabolism, and structural organization. They are often classified as moonlighting or promiscuous enzymes. Moonlighting enzymes possess at least one catalytic domain and an additional noncatalytic domain that execute independent functions. In contrast, promiscuous enzymes are defined by catalytic domains capable of performing distinct activities.
This Special Issue, Multifunctional Enzymes and Proteins: New Insights into Structure and Function, will gather cutting-edge research highlighting the complexity and versatility of these biomolecules and offering new perspectives on evolutionary innovation and biological efficiency. Importantly, dysfunction or misregulation of these versatile proteins is often implicated in diseases such as cancer, metabolic disorders, and neurodegeneration.
Understanding the structural determinants and mechanisms that allow a single polypeptide chain to perform multiple, seemingly unrelated functions is essential for advancing therapeutic and biotechnological applications. By integrating structural biology, biophysics, computational modeling, and biochemical approaches, this Special Issue will deepen our knowledge of multifunctional proteins and open new avenues for drug discovery, synthetic biology, and industrial biotechnology.
Dr. Martina Buonanno
Dr. Paola Imbimbo
Dr. Fabiola Mascanzoni
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- multifunctional enzymes
- protein structure
- protein function
- catalytic activity
- conformational dynamics
- biochemistry
- biophysics
- drug discovery
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