Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), represent a growing global health challenge, affecting millions and leading to significant morbidity and mortality. These conditions are characterized by progressive neuronal loss and the deterioration of critical brain functions, often resulting in memory impairment, motor dysfunction, and a decline in cognitive and physical abilities. Despite substantial advances in understanding the pathophysiology of these disorders, effective disease-modifying therapies remain elusive.

Recent insights into the molecular mechanisms underlying neurodegenerative diseases have opened new avenues for therapeutic exploration. Key areas of focus include the accumulation of misfolded proteins, mitochondrial dysfunction, oxidative stress, neuroinflammation, and genetic mutations that drive disease pathology. Understanding these complex and often interconnected pathways has catalyzed the development of novel approaches, including gene therapy, RNA-based therapies, small-molecule inhibitors, and immunotherapy.

This Special Issue, "Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases", aims to gather pioneering research that explores these molecular underpinnings and innovative treatment strategies. We welcome studies that delve into cellular pathways involved in disease progression, as well as translational research efforts focused on developing targeted and personalized therapies. By addressing challenges such as drug delivery across the blood–brain barrier, off-target effects, and long-term efficacy, this Issue aspires to drive forward the search for effective treatments, providing hope for patients and families affected by neurodegenerative disorders.

Dr. Zhidong Zhou
Guest Editor

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