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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 30 Jul 2026 | 2 articles | Viewed by 4437 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches

edited by

Nikolaos Theodorakis

and Maria Nikolaou

submission deadline 31 Jul 2026 | 6 articles | Viewed by 37551 | Submission Open

Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 31 Jul 2026 | 4 articles | Viewed by 18706 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 31 Jul 2026 | 4 articles | Viewed by 13072 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Jul 2026 | 5 articles | Viewed by 10816 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 31 Jul 2026 | 3 articles | Viewed by 10087 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Jul 2026 | 7 articles | Viewed by 8750 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability

edited by

Peter Celec

submission deadline 31 Jul 2026 | 2 articles | Viewed by 8121 | Submission Open

Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6293 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Novel Mechanisms of Bacterial Antibiotic Resistance

edited by

Dorothea K. Thompson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 6287 | Submission Open

Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches

(This special issue belongs to the Section Biological Factors)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5662 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Jul 2026 | 5 articles | Viewed by 5503 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3223 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2865 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Heterocyclic Compounds: Synthesis, Characterization, and Validation

edited by

Monika Pitucha

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2783 | Submission Open

Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism

edited by Udai P. Singh

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2176 | Submission Open

Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease

(This special issue belongs to the Section Biological Factors)

Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1725 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol–protein interactions; ethanol–membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1412 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene–environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1393 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1204 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Skeletal Muscle Growth and Loss in Health, Aging, and Disease

edited by

Khaled Kamal

submission deadline 31 Jul 2026 | Viewed by 755 | Submission Open

Keywords: skeletal muscle; muscle growth and atrophy; metabolic signaling (anabolic/catabolic); mechanotransduction; redox biology and oxidative stress; inflammation and immune signaling; obesity and metabolic disease; sarcopenia and aging; cachexia and neuromuscular disease; extracellular vesicles and exosomes

(This special issue belongs to the Section Molecular Biology)

Metabolic and Signaling Networks in Therapy Resistance

edited by

Jun He

and Lei Zhao

submission deadline 31 Jul 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: therapeutic resistance; metabolic reprogramming; systems biology; signaling networks

(This special issue belongs to the Section Molecular Medicine)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jul 2026 | Viewed by 585 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 31 Jul 2026 | Viewed by 413 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

Hepatic Stellate Cells and Immune Microenvironment in Hepatocellular Carcinoma

edited by

Tai-long Pan

submission deadline 31 Jul 2026 | Viewed by 335 | Submission Open

Keywords: hepatic stellate cell; hepatocellular carcinoma; immune microenvironment; extracellular matrix; epigenetics; tumor microenvironment; inflammation

(This special issue belongs to the Section Molecular Medicine)

Design and Applications of 3D Bioprinting

edited by

Saman Naghieh

and

Chaozong Liu

submission deadline 31 Jul 2026 | Viewed by 311 | Submission Open

Keywords: 3D bioprinting; biofabrication; tissue engineering; regenerative medicine; smart biomaterials; scaffold design; organ models; personalized therapeutics; biomedical additive manufacturing; translational bioprinting

(This special issue belongs to the Section Bio-Engineered Materials)

Cellular and Molecular Mechanisms of Autoimmune Diseases

edited by Ming-Lin Liu

submission deadline 31 Jul 2026 | Viewed by 308 | Submission Open

Keywords: autoimmune diseases; genetic and epigenetic; immune tolerance; T and B cell pathways; cytokines; molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Tracking Aging and Stress: Omics-Based Insights into Physiology and Pathology

edited by

Dominika Drulis-Fajdasz

submission deadline 31 Jul 2026 | Viewed by 305 | Submission Open

Keywords: genetic proteomic; lipidomic metabolomic; aging senescence; neurodegeneration; cellular stress

(This special issue belongs to the Section Biological Factors)

Sterol Biosynthesis in Organisms

edited by Damjana Rozman and

Cene Skubic

submission deadline 31 Jul 2026 | Viewed by 302 | Submission Open

Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases

(This special issue belongs to the Section Cellular Biochemistry)

Protein Spreading in Neurodegenerative Diseases: From Mechanisms to Therapeutics

edited by

Xiaobo Mao

and

Enrico Moro

submission deadline 31 Jul 2026 | Viewed by 286 | Submission Open

Keywords: neurodegeneration; protein aggregation; Alzheimer disease; Lewy bodies; frontotemporal dementia

(This special issue belongs to the Section Molecular Medicine)

Mutagenesis and Genetic Instability in Genome Evolution and in Cancer: Mechanisms, Consequences, and Therapeutic Perspectives

edited by

Said Aoufouchi

and Rabii Ameziane El Hassani

submission deadline 31 Jul 2026 | Viewed by 263 | Submission Open

Keywords: genomic instability; mutagenesis; evolution; genetic diversification DNA repair; epigenetic; cancers; therapy resistance

(This special issue belongs to the Section Molecular Biology)

Significance of KEAP1 and NRF2 Protein-Protein Interactions in Cancer

edited by

Mihaela Matovina

submission deadline 31 Jul 2026 | Viewed by 226 | Submission Open

Keywords: cancer; protein–protein interactions (PPIs); KEAP1; NRF2

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Microbial Biocontrol and Plant-Microbe Interactions, 2nd Edition

edited by

Shahzad Munir

submission deadline 31 Jul 2026 | Viewed by 220 | Submission Open

Keywords: endophytic microbiome for disease management; plant–microbe interactions; microbial colonization for disease control; plant–insect–pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Immune Cells in Human Arterial Diseases

edited by

Klaus Ley

submission deadline 14 Aug 2026 | Viewed by 220 | Submission Open

Keywords: carotid artery; endarterectomy; atherosclerosis; macrophage; lymphocytes; T cells; autoimmunity; smooth muscle cells; endothelial cells

(This special issue belongs to the Section Biological Factors)

From Target Antigens to Companion Diagnostics: Antibody-Based Therapies in Women’s Cancers

edited by

Salvatore Cortellino

and

Canio Martinelli

submission deadline 15 Aug 2026 | 1 articles | Viewed by 852 | Submission Open

Keywords: antibody–drug conjugate (ADC); antibody therapy; bispecific antibody; companion diagnostics; biomarker thresholds; immunohistochemistry; FRα; HER2; tissue factor; spatial heterogeneity; tumor penetration; endocytosis/trafficking; bystander effect; resistance mechanisms

(This special issue belongs to the Section Molecular Reproduction)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 20 Aug 2026 | 3 articles | Viewed by 14652 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

submission deadline 20 Aug 2026 | 4 articles | Viewed by 6339 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 20 Aug 2026 | Viewed by 577 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 20 Aug 2026 | Viewed by 486 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

(This special issue belongs to the Section Chemical Biology)

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 20 Aug 2026 | Viewed by 405 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

edited by

Rui Li

and Xinmin Li

submission deadline 20 Aug 2026 | Viewed by 301 | Submission Open

Keywords: multiomics and bioinformatics; functional genomics; molecular breeding; molecular plant biology; functional genomics; sustainable agricultural biotechnology; nutrition and health of functional foods

(This special issue belongs to the Section Molecular Genetics)

The Role of Non-Coding RNAs in Health and Disease: 2nd Edition

edited by

Narasimman Gurusamy

submission deadline 25 Aug 2026 | 2 articles | Viewed by 2367 | Submission Open

Keywords: non-coding RNA,; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 25 Aug 2026 | Viewed by 326 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Aug 2026 | Viewed by 802 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Bioactive Compounds in Dermatology

edited by

Gaewon Nam

submission deadline 30 Aug 2026 | Viewed by 321 | Submission Open

Keywords: bioactive compounds; cosmetic active ingredients; dermatology; skin bioengineering; skin biology

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Molecular and Cellular Mechanisms in Multiple Sclerosis

edited by

Magdalena Zoledziewska

and Maria laura Idda

submission deadline 30 Aug 2026 | Viewed by 271 | Submission Open

Keywords: multiple sclerosis; gene expression; immunophenotyping; molecular-, expression- and protein-quantitative loci QTLs; non-coding RNAs; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Glycosylation: Cutting-Edge Approach to Targeted Therapy in Cancer

edited by

Myron R. Szewczuk

submission deadline 30 Aug 2026 | Viewed by 219 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 Aug 2026 | 12 articles | Viewed by 31017 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Aug 2026 | 6 articles | Viewed by 14563 | Submission Open

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Aug 2026 | 1 articles | Viewed by 13360 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

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