Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 23
Special Issue Editors
Interests: alcohol-related medicine; atherosclerosis; blood lipid-related index; cardiovascular risk factors; thrombosis and hemostasis; vascular biology
Special Issues, Collections and Topics in MDPI journals
Interests: ion channels; Ca2+ signaling; TRP proteins; regulatory lipid–protein interactions; membrane micro- and nanodomains; photopharmacology; opto-chemogenetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Habitual alcohol drinking exerts a complex and diverse impact on our societies and determines population health, aging, and life expectancy. The individual consequences of alcohol consumption depend on the dose and frequency of intake as well as on gender and genetic and social background. There is an ongoing and fairly controversial discussion on the impact of alcohol consumption on cardiovascular health. Although there is a general consensus on the role of excessive drinking as a trigger of cardiovascular malfunction and a driver of disease progression, the incidence of some cardiovascular morbidities, such as ischemic heart disease, appears surprisingly lower in light-to-moderate drinkers than in non-drinkers. The complexity and heterogeneity of individual cardiovascular consequences of ethanol intake are based on factors determining individual susceptibility, such as age, gender, ethnicity, and genetic predisposition, as well as controllable risk factors, including obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome. Clear delineation of the pathological relevance of habitual alcohol drinking and the establishment of preventive measures to minimize the drinking-associated cardiovascular risk in our societies appear overdue. Such progress inevitably requires a comprehensive understanding of the molecular mechanisms underlying the effects of ethanol on the cardiovascular system. Remarkable conceptual advances have recently been made regarding the molecular interactions between ethanol as well as its major metabolites and cellular signal transduction processes. Moreover, critical target structures for ethanol and its metabolites have been identified throughout the cardiovascular system.
This Special Issue of Biomolecules shall serve as a platform to present and discuss new concepts in ethanol pharmacology/toxicology, providing an outlook towards the rational design of effective strategies to minimize deleterious consequences of alcohol consumption in general and specifically with respect to cardiovascular health in our societies.
Prof. Dr. Ichiro Wakabayashi
Prof. Dr. Klaus Groschner
Guest Editors
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Keywords
- alcohol
- ethanol metabolism
- ethanol–protein interactions
- ethanol–membrane interactions
- cardiovascular health and disease
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