Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 5
Special Issue Editor
Interests: neuroimaging; inborn errors of metabolism; neurogenetics; neuroscience; neurodevelopmental disorders; genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodevelopmental disorders (NDDs) including autism spectrum disorder, intellectual disabilities, and epilepsy represent a complex interplay between genetic and epigenetic factors. While advances in genomics have revealed numerous causative variants in critical genes, growing evidence highlights a role of epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNA, in modulating gene expression during brain development. This Special Issue will highlight recent breakthroughs in identifying both rare and common genetic variants, the epigenomic landscapes of early neural development, and how the environment also influences and shapes NDD risk. We encourage submissions that utilize multi-omics, animal, or organoid models and systems biology approaches to deepen our understanding of the pathogenesis of NDDs as a pathway for exploring new therapeutic targets.
Dr. Andrea L. Gropman
Guest Editor
Manuscript Submission Information
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Keywords
- neurodevelopmental disorders
- epigenetics
- gene–environment interaction
- chromatin remodeling
- neurogenomics
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